2. Gene
  3. Dhh - desert hedgehog Gene

Dhh - desert hedgehog Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13363 | Gene type: protein coding

About Dhh

Summary

Enables patched binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; gut; heart and pericardium; nervous system; and yolk sac. Used to study 46,XY sex reversal. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Dhh Products(1)

mRNA Protein Name
NM_007857.5 NP_031883.1 desert hedgehog protein preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables patched binding IPI
IPI: Inferred from physical interaction
9811851 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10050855 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Leydig cell differentiation IGI
IGI: Inferred from genetic interaction
17495005 MGI
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
12050120 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10482238 MGI
involved in male gonad development IMP
IMP: Inferred from mutant phenotype
8805249 MGI
acts upstream of or within male sex determination IGI
IGI: Inferred from genetic interaction
17495005 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: Inferred from direct assay
25639508 MGI
involved in paracrine signaling IMP
IMP: Inferred from mutant phenotype
32151560 MGI
acts upstream of or within regulation of steroid biosynthetic process IGI
IGI: Inferred from genetic interaction
17495005 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
25639508 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
17495005 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
8805249 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desert hedgehog protein

HHG-3

Recombinant Dhh Proteins

Cat. No. Product Name Accession Purity
HY-P7339 DHH Protein, Mouse Q61488 (C23-G198, C23I) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03733 DHH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhh NCBI NCBI:50846