2. Gene
  3. Dsg2 - desmoglein 2 Gene

Dsg2 - desmoglein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D18Ertd293e

Gene ID: 13511 | Gene type: protein coding

About Dsg2

Summary

This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the Cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]

Dsg2 Products(1)

mRNA Protein Name
NM_007883.3 NP_031909.2 desmoglein-2 preproprotein
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in desmosome IDA
IDA: Inferred from direct assay
9864371 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmoglein-2

Recombinant Dsg2 Proteins

Cat. No. Product Name Accession Purity
HY-P77918 DSG2/Desmoglein-2 Protein, Mouse (HEK293, His) O55111 (A55-A618) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04022 DSG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsg2 NCBI NCBI:1829