2. Gene
  3. Dsg3 - desmoglein 3 Gene

Dsg3 - desmoglein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as bal

Gene ID: 13512 | Gene type: protein coding

About Dsg3

Summary

This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the Cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein exhibit loss of keratinocyte cell adhesion resulting in a phenotype that resembles that of patients with pemphigus vulgaris. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]

Dsg3 Products(1)

mRNA Protein Name
NM_030596.4 NP_085099.2 desmoglein-3 preproprotein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein dimerization activity IDA
IDA: Inferred from direct assay
30949721 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmoglein-3

130 kDa pemphigus vulgaris antigen homolog

Recombinant Dsg3 Proteins

Cat. No. Product Name Accession Purity
HY-P72175 DSG3 Protein, Mouse (His-SUMO) O35902 (E50-P617) ≥95%
HY-P78291 DSG3 Protein, Mouse (HEK293, His) O35902-1 (E50-P617) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04023 DSG3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsg3 NCBI NCBI:1830