APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

Homo sapiens

Also known as A3D; A3DE; ARP6; APOBEC3E; APOBEC3DE

Gene ID: 140564 | Gene type: protein coding

About APOBEC3D

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,021,127-39,033,277 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 5.2), spleen (RPKM 4.6) and 22 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

APOBEC3D Products(2)

mRNA	Protein	Name
NM_001363781.1	NP_001350710.1	DNA dC->dU-editing enzyme APOBEC-3D isoform 2
NM_152426.4	NP_689639.2	DNA dC->dU-editing enzyme APOBEC-3D isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA cytosine deamination	IDA IDA: Inferred from direct assay	21835787	GOA
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21835787	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	21835787	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	22915799	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21835787	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3D Protein Structure

APOBEC_N

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3D

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

Related Diseases

Diseases

Alias

Brachydactyly, Type A3

Brachydactyly Type A3	BDA3
Brachydactyly-Clinodactyly	Brachymesophalangy V
Brachymesophalangy 5	Brachydactyly Clinodactyly

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00838	APOBEC3D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3D	MGD	MGI:1933111

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