2. Gene
  3. Fkbp1a - FK506 binding protein 1a Gene

Fkbp1a - FK506 binding protein 1a Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fkbp; Fkbp1; FKBP12

Gene ID: 14225 | Gene type: protein coding

About Fkbp1a

Summary

This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta Receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Fkbp1a Products(7)

mRNA Protein Name
NM_001302077.1 NP_001289006.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1
NM_001302078.1 NP_001289007.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 2
NM_001302079.1 NP_001289008.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 3
NM_001302080.1 NP_001289009.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 3
NM_001355077.1 NP_001342006.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 2
NM_001355078.1 NP_001342007.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 4
NM_008019.3 NP_032045.1 peptidyl-prolyl cis-trans isomerase FKBP1A isoform 1
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP1A

FK506 binding protein 12

PPIase FKBP1A

calstabin-1

immunophilin FKBP12

Recombinant Fkbp1a Proteins

Cat. No. Product Name Accession Purity
HY-P76346 FKBP12 Protein, Mouse (His) P26883 (G2-E108) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04960 FKBP1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp1a NCBI NCBI:2280