Gfap - glial fibrillary acidic protein Gene

Mus musculus

Gene ID: 14580 | Gene type: protein coding

About Gfap

Summary

A structural constituent of Cytoskeleton. Involved in regulation of chaperone-mediated Autophagy. Acts upstream of or within with a positive effect on D-aspartate import across plasma membrane; gene expression; and intracellular protein transport. Acts upstream of or within several processes, including intermediate filament organization; long-term synaptic potentiation; and neurogenesis. Located in several cellular components, including astrocyte end-foot; cell body; and intermediate filament. Is expressed in several structures, including alimentary system; hemolymphoid system; integumental system; nervous system; and sensory organ. Used to study Alexander disease. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Apr 2022]

Gfap Products(2)

mRNA	Protein	Name
NM_001131020.1	NP_001124492.1	glial fibrillary acidic protein isoform 1
NM_010277.3	NP_034407.2	glial fibrillary acidic protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12403814	MGI
enables structural constituent of cytoskeleton	IMP IMP: Inferred from mutant phenotype	12177195	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Bergmann glial cell differentiation	IMP IMP: Inferred from mutant phenotype	10816608	MGI
acts upstream of or within positive effect D-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15135219	MGI
acts upstream of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	16988027	MGI
acts upstream of or within astrocyte development	IGI IGI: Inferred from genetic interaction	11487638	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	11487638	MGI
acts upstream of or within positive effect gene expression	IMP IMP: Inferred from mutant phenotype	15135219	MGI
acts upstream of or within intermediate filament organization	IGI IGI: Inferred from genetic interaction	11487638	MGI
acts upstream of or within intermediate filament organization	IMP IMP: Inferred from mutant phenotype	8692820	MGI
acts upstream of or within intermediate filament-based process	IMP IMP: Inferred from mutant phenotype	12177195	MGI
acts upstream of or within positive effect intracellular protein transport	IMP IMP: Inferred from mutant phenotype	15135219	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	8692820	MGI
acts upstream of or within negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	11487638	MGI
acts upstream of or within negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	11487638	MGI
acts upstream of neuron projection development	IGI IGI: Inferred from genetic interaction	11487638	MGI
acts upstream of neuron projection development	IMP IMP: Inferred from mutant phenotype	11487638	MGI
acts upstream of or within neuron projection regeneration	IMP IMP: Inferred from mutant phenotype	16988027	MGI
acts upstream of or within positive regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	16988027	MGI
involved in regulation of chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	20797626	MGI
acts upstream of or within regulation of neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	15135219	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	21212183	MGI
located in astrocyte projection	IDA IDA: Inferred from direct assay	19646951	MGI
located in cell body	IDA IDA: Inferred from direct assay	8793730	MGI
located in cell projection	IDA IDA: Inferred from direct assay	10989258	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11064363	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	29350434	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	20531390	MGI
located in intermediate filament	IDA IDA: Inferred from direct assay	9364068	MGI
located in membrane	IDA IDA: Inferred from direct assay	11283023	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glial fibrillary acidic protein

intermediate filament protein

Recombinant Gfap Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72203	GFAP Protein, Mouse (His-SUMO)	P03995 (M1-M430)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3392	Zilganersen		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148013	K284-6111	Inhibitor	≥98.0%	Unkown
HY-W019710	(E,E)-RGFP966	Inhibitor	99.31%	Unkown
HY-P3392A	Zilganersen sodium	Inhibitor	91.43%	Unkown
HY-RS05376	GFAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gfap	NCBI	NCBI:2670

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