Hsp90aa1 - heat shock protein 90, alpha (cytosolic), class A member 1 Gene

Mus musculus

Also known as hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1

Gene ID: 15519 | Gene type: protein coding

About Hsp90aa1

Chromosome 12: 110,657,039-110,669,162 reverse strand.GRCm39:CM001005.3

This gene has 8 transcripts (splice variants), 277 orthologues, 3 paralogues and is associated with 36 phenotypes. Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues.

Summary

Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including axonogenesis; positive regulation of nitrogen compound metabolic process; and positive regulation of protein kinase B signaling. Located in several cellular components, including growth cone; neuronal cell body; and ruffle membrane. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90aa1 Products(1)

mRNA	Protein	Name
NM_010480.5	NP_034610.1	heat shock protein HSP 90-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12885400	MGI
enables nitric-oxide synthase regulator activity	IDA IDA: Inferred from direct assay	12855682	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12855682	MGI
enables protein folding chaperone	IMP IMP: Inferred from mutant phenotype	24286867	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	27496612	MGI
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	12855682	MGI
involved in protein folding	IMP IMP: Inferred from mutant phenotype	27496612	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	24286867	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	24286867	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17908927	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17923681	MGI
located in dendritic growth cone	IDA IDA: Inferred from direct assay	24286867	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	9122205	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	24286867	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24286867	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27496612	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hsp90aa1 Protein Structure

PRK14083

0
200
400
600
733 a.a.

Protein Preferred Names

Protein Names

heat shock protein HSP 90-alpha

HSP 86	HSP86
TSTA	heat shock 86 kDa
heat shock protein 1, alpha	heat shock protein 90kDa alpha (cytosolic), class A member 1
heat shock protein, 1	heat shock protein, 86 kDa 1
heat shock protein, 89 kDa	tumor-specific transplantation 86 kDa antigen

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06415	HSP90AA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06416	Hsp90aa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06417	Hsp90aa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hsp90aa1	NCBI	NCBI:3320

Name
Email *

	Sorry, but the email address you supplied was invalid.