Htr1a - 5-hydroxytryptamine (serotonin) receptor 1A Gene

Mus musculus

Also known as Gpcr18

Gene ID: 15550 | Gene type: protein coding

About Htr1a

Chromosome 13: 105,580,147-105,584,630 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 149 orthologues, 32 paralogues and is associated with 12 phenotypes.

Summary

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; serotonin metabolic process; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Htr1a Products(1)

mRNA	Protein	Name
NM_008308.5	NP_032334.2	5-hydroxytryptamine receptor 1A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	8254366	MGI
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	9826725	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	9826725	MGI
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	9826725	MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway	IMP IMP: Inferred from mutant phenotype	16925594	MGI
involved in regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11080193	MGI
involved in regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	9826725	MGI
involved in serotonin metabolic process	IMP IMP: Inferred from mutant phenotype	11080193	MGI
involved in serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9826725	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr1a Protein Structure

7tmA_5-HT1A_vertebrates

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 1A

5-HT-1A	5-HT1A receptor
G-protein coupled receptor 18	serotonin receptor 1A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06458	HTR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06459	Htr1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06460	Htr1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr1a	NCBI	NCBI:3350

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