CDCA2 - cell division cycle associated 2 Gene

Homo sapiens

Also known as PPP1R81; Repo-Man

Gene ID: 157313 | Gene type: protein coding

About CDCA2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,458,931-25,507,917 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues and 1 paralogue. Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues.

Summary

This gene encodes a targeting subunit of the cell-cycle associated protein, protein Phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a Phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in Cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

CDCA2 Products(3)

mRNA	Protein	Name
NM_001317906.1	NP_001304835.1	cell division cycle-associated protein 2 isoform 2
NM_001317907.1	NP_001304836.1	cell division cycle-associated protein 2 isoform 3
NM_152562.4	NP_689775.2	cell division cycle-associated protein 2 isoform 1

CDCA2 Protein Structure

PP1_bind

0
200
400
600
800
1023 a.a.

Protein Preferred Names

Protein Names

cell division cycle-associated protein 2

protein phosphatase 1, regulatory subunit 81

Related Diseases

Diseases

Alias

Uterine Adnexa Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02311	CDCA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDCA2	VGNC	VGNC:60666
Macaca mulatta	CDCA2	VGNC	VGNC:70710
Rattus norvegicus	CDCA2	RGD	RGD:1311003
Bos taurus	CDCA2	VGNC	VGNC:59194
Canis familiaris	CDCA2	VGNC	VGNC:39012
Mus musculus	CDCA2	MGD	MGI:1919787

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