Ighg1 - immunoglobulin heavy constant gamma 1 (G1m marker) Gene

Mus musculus

Also known as IgG1; Igh-4; VH7183

Gene ID: 16017 | Gene type: other

About Ighg1

Summary

Enables antigen binding activity and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Located in external side of plasma membrane and extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antigen binding	IDA IDA: Inferred from direct assay	4098598	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IGI IGI: Inferred from genetic interaction	28923960	MGI
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	28923960	MGI
acts upstream of or within antibacterial humoral response	IDA IDA: Inferred from direct assay	9834074	MGI
acts upstream of or within antibody-dependent cellular cytotoxicity	IDA IDA: Inferred from direct assay	9743367	MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin	IDA IDA: Inferred from direct assay	8041705	MGI
acts upstream of or within immunoglobulin mediated immune response	IDA IDA: Inferred from direct assay	4098598	MGI
involved in immunoglobulin production	IMP IMP: Inferred from mutant phenotype	28923960	MGI
acts upstream of or within phagocytosis, engulfment	IDA IDA: Inferred from direct assay	8769481	MGI
acts upstream of or within phagocytosis, recognition	IDA IDA: Inferred from direct assay	8769481	MGI
acts upstream of or within positive regulation of immune response	IDA IDA: Inferred from direct assay	10395649	MGI
acts upstream of or within positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	8769481	MGI
acts upstream of or within positive regulation of type I hypersensitivity	IDA IDA: Inferred from direct assay	8552190	MGI
acts upstream of or within positive regulation of type IIa hypersensitivity	IDA IDA: Inferred from direct assay	9834201	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	28923960	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	18762567	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9707605	MGI
part of immunoglobulin complex, circulating	IDA IDA: Inferred from direct assay	4098598	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Recombinant Ighg1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73901	IgG1 Protein, Mouse (HEK293, C102S)	P01868-1 (V98-K324, C102S)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99844	Davoceticept		/	Phase 1

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ighg1	NCBI	NCBI:3500

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