Pgr - progesterone receptor Gene

Mus musculus

Also known as PR; PR-A; PR-B; NR3C3; 9930019P03Rik

Gene ID: 18667 | Gene type: protein coding

About Pgr

Chromosome 9: 8,899,834-8,968,612 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 193 orthologues, 8 paralogues and is associated with 51 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 5.5), ovary adult (RPKM 4.9) and 6 other tissues.

Summary

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. [provided by RefSeq, Sep 2015]

Pgr Products(1)

mRNA	Protein	Name
NM_008829.2	NP_032855.2	progesterone receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor activity	IMP IMP: Inferred from mutant phenotype	14681235	MGI
enables nuclear steroid receptor activity	IDA IDA: Inferred from direct assay	16176985	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	14765981	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	14765981	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	24190884	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	12897242	MGI
acts upstream of or within ovulation from ovarian follicle	IMP IMP: Inferred from mutant phenotype	12897242	MGI
acts upstream of or within paracrine signaling	IMP IMP: Inferred from mutant phenotype	24190884	MGI
acts upstream of or within progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	16176985	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14681235	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12897242	MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	10733525	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pgr Protein Structure

Prog_receptor

NR_DBD_GR_PR

NR_LBD_PR

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

progesterone receptor

nuclear receptor subfamily 3 group C member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10396	PGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10397	Pgr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10398	Pgr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pgr	NCBI	NCBI:5241

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