Pik3cd - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Gene

Mus musculus

Also known as p110delta; 2410099E07Rik; 2610208K16Rik

Gene ID: 18707 | Gene type: protein coding

About Pik3cd

Chromosome 4: 149,733,625-149,787,028 reverse strand.GRCm39:CM000997.3

This gene has 14 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 40 phenotypes. Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues.

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cd Products(6)

mRNA	Protein	Name
NM_001164049.1	NP_001157521.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b
NM_008840.3	NP_032866.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform c
NM_001029837.2	NP_001025008.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b
NM_001164051.1	NP_001157523.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform e
NM_001164052.1	NP_001157524.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a
NM_001164050.1	NP_001157522.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform d

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22020336	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell activation	IMP IMP: Inferred from mutant phenotype	12235209	MGI
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	12235209	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12235209	MGI
acts upstream of or within defense response to fungus	IMP IMP: Inferred from mutant phenotype	24009720	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	24009720	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	31915155	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	31915155	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24009720	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cd Protein Structure

PI3K_p85B

PI3K_rbd

C2_PI3K_class_I_beta_delta

PI3Ka

PI3Kc_IA_delta

0
200
400
600
800
1043 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PI3-kinase subunit delta	PI3K-delta
PI3Kdelta	catalytic phosphatidylinositol 3-kinase delta
p100 delta	phosphatidylinositol 3-kinase catalytic delta polypeptide
phosphatidylinositol 3-kinase catalytic subunit delta	phosphatidylinositol 3-kinase p110 delta
phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta	phosphoinositide 3 kinase P110delta
ptdIns-3-kinase subunit delta	ptdIns-3-kinase subunit p110-delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161366	OMS14	Inhibitor	99.09%	Unkown
HY-RS10529	PIK3CD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10530	Pik3cd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10531	Pik3cd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3cd	NCBI	NCBI:5293

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