Serpinf2 - serine (or cysteine) peptidase inhibitor, clade F, member 2 Gene

Mus musculus

Also known as Pli; Serpimf2

Gene ID: 18816 | Gene type: protein coding

About Serpinf2

Summary

Predicted to enable protease binding activity; protein homodimerization activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including collagen fibril organization; maintenance of blood vessel diameter homeostasis by renin-angiotensin; and positive regulation of biosynthetic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including liver; pancreas epithelium; urinary system; and yolk sac. Used to study alpha-2-plasmin inhibitor deficiency. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Apr 2022]

Serpinf2 Products(1)

mRNA	Protein	Name
NM_008878.2	NP_032904.1	alpha-2-antiplasmin precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18436805	MGI
involved in collagen fibril organization	IMP IMP: Inferred from mutant phenotype	17958745	MGI
involved in maintenance of blood vessel diameter homeostasis by renin-angiotensin	IMP IMP: Inferred from mutant phenotype	18436805	MGI
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	20008146	MGI
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	18436805	MGI
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18436805	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17958745	MGI
involved in positive regulation of transforming growth factor beta production	IMP IMP: Inferred from mutant phenotype	17958745	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-2-antiplasmin

alpha-2-AP	alpha-2-PI
alpha-2-plasmin inhibitor	pigment epithelium derived factor
plasmin inhibitor alpha 2	serine (or cysteine) proteinase inhibitor, clade F, member 2
serpin F2

Recombinant Serpinf2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71295	Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His)	Q61247 (V28-K491)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12726	SERPINF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Serpinf2	NCBI	NCBI:5345
Macaca fascicularis	Serpinf2	NCBI	NCBI:102116557

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