DNAH10 - dynein axonemal heavy chain 10 Gene

Homo sapiens

Also known as SPGF56

Gene ID: 196385 | Gene type: protein coding

About DNAH10

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,762,301-123,935,720 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 238 orthologues, 15 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 3.1), bone marrow (RPKM 0.9) and 3 other tissues.

Summary

Dyneins are microtubule-associated motor protein complexes composed of several heavy, LIGHT, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]

DNAH10 Products(2)

mRNA	Protein	Name
NM_001372106.1	NP_001359035.1	dynein axonemal heavy chain 10 isoform 3
NM_207437.3	NP_997320.2	dynein axonemal heavy chain 10 isoform 1

DNAH10 Protein Structure

DHC_N1

DHC_N2

AAA_6

AAA_5

AAA_7

AAA_8

AAA_9

Dynein_heavy

0
700
1400
2100
2800
3500
4200
4471 a.a.

Protein Preferred Names

Protein Names

dynein axonemal heavy chain 10

axonemal beta dynein heavy chain 10

Related Diseases

Diseases

Alias

Spermatogenic Failure 56

SPGF56

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Lipodystrophy, Familial Partial, Type 1

FPLD1	Familial Partial Lipodystrophy Type 1
Familial Partial Lipodystrophy, Kobberling Type	Lipodystrophy, Familial Partial, Kobberling Type
Familial Partial Lipodystrophy Kobberling Type	Familial Partial Lipodystrophy Type Köbberling
Familial Partial Lipodystrophy, Köbberling Type	Familial Partial Lipodystrophy, Type 1

Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay

CAKUTHED	Doid:0112359
Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03843	DNAH10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAH10	VGNC	VGNC:61542
Canis familiaris	DNAH10	VGNC	VGNC:40012
Mus musculus	DNAH10	MGD	MGI:1860299
Bos taurus	DNAH10	VGNC	VGNC:28123
Rattus norvegicus	DNAH10	RGD	RGD:619988

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