Sema4a - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Gene

Mus musculus

Also known as SemB; Semab

Gene ID: 20351 | Gene type: protein coding

About Sema4a

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in several processes, including T-helper 1 cell differentiation; negative regulation of angiogenesis; and positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; primitive ventricle; retina; and ureteric trunk. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A). [provided by Alliance of Genome Resources, Apr 2022]

Sema4a Products(4)

mRNA	Protein	Name
NM_001163489.1	NP_001156961.1	semaphorin-4A precursor
NM_001163490.1	NP_001156962.1	semaphorin-4A precursor
NM_001163491.1	NP_001156963.1	semaphorin-4A precursor
NM_013658.3	NP_038686.3	semaphorin-4A precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation involved in immune response	IMP IMP: Inferred from mutant phenotype	15780988	MGI
involved in T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	15780988	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	20043131	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17318185	MGI
involved in positive regulation of excitatory synapse assembly	IMP IMP: Inferred from mutant phenotype	29981480	MGI
involved in positive regulation of inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	29981480	MGI
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	20043131	MGI
involved in regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17318185	MGI
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	20043131	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	17318185	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-4A

sema B

semaphorin-B

Recombinant Sema4a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71283	Semaphorin-4A/SEMA4A Protein, Mouse (HEK293, His)	Q62178 (T33-H682)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12657	SEMA4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema4a	NCBI	NCBI:64218

Name
Email *

	Sorry, but the email address you supplied was invalid.