MTLN - mitoregulin Gene

Homo sapiens

Also known as MPM; LEMP; MOXI; SMIM37; LINC00116; NCRNA00116

Gene ID: 205251 | Gene type: protein coding

About MTLN

This gene has 3 transcripts (splice variants) and 137 orthologues. Ubiquitous expression in fat (RPKM 3.7), kidney (RPKM 3.7) and 25 other tissues.

Summary

Involved in several processes, including fatty acid beta-oxidation; positive regulation of mitochondrial membrane potential; and triglyceride homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MTLN Products(1)

mRNA	Protein	Name
NM_001384134.1	NP_001371063.1	mitoregulin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32243843	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	32243843	GOA
involved in positive regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	29949756	GOA
involved in positive regulation of sequestering of calcium ion	IDA IDA: Inferred from direct assay	29949756	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	32243843	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	32243843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitoregulin

lncRNA encoded micropeptide

Related Diseases

Diseases

Alias

Joubert Syndrome 4

JBTS4	Joubert Syndrome With Renal Defect
Joubert Syndrome With Renal Anomalies	Js-R
Joubert Syndrome, Type 4

Nephronophthisis 1

NPHP1	Nephronophthisis, Familial Juvenile
Nph1	Nephronophthisis 1, Juvenile
Juvenile Nephronophthisis 1	Familial Juvenile Nephronophthisis 1
Nephronophthisis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08783	MTLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MTLN	MGD	MGI:1915135
Rattus norvegicus	MTLN	RGD	RGD:10401149

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