STX2 - syntaxin 2 Gene

Homo sapiens

Also known as EPM; EPIM; STX2A; STX2B; STX2C

Gene ID: 2054 | Gene type: protein coding

About STX2

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,789,600-130,839,250 (from NCBI)

This gene has 13 transcripts (splice variants), 254 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 4.3), lung (RPKM 3.9) and 25 other tissues.

Summary

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

STX2 Products(9)

mRNA	Protein	Name
NM_001351049.2	NP_001337978.2	syntaxin-2 isoform 3
NM_001351050.2	NP_001337979.1	syntaxin-2 isoform 4
NM_001351051.2	NP_001337980.1	syntaxin-2 isoform 5
NM_001351052.2	NP_001337981.1	syntaxin-2 isoform 6
NM_001413773.1	NP_001400702.1	syntaxin-2 isoform 7
NM_001413774.1	NP_001400703.1	syntaxin-2 isoform 8
NM_001413775.1	NP_001400704.1	syntaxin-2 isoform 2
NM_001980.5	NP_001971.2	syntaxin-2 isoform 1
NM_194356.4	NP_919337.1	syntaxin-2 isoform 2

STX2 Protein Structure

Syntaxin

SNARE

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

syntaxin-2

epimorphin

Related Diseases

Diseases

Alias

Acute Diarrhea

Dysentery

Infectious Diarrhea

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13982	STX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STX2	VGNC	VGNC:35438
Rattus norvegicus	STX2	RGD	RGD:2558
Canis familiaris	STX2	VGNC	VGNC:49890
Felis catus	STX2	VGNC	VGNC:65812
Mus musculus	STX2	MGD	MGI:108059
Macaca mulatta	STX2	VGNC	VGNC:78259
Others	STX2	NCBI

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