Tek - TEK receptor tyrosine kinase Gene

Mus musculus

Also known as Hyk; STK1; Tie2; Tie-2; Cd202b

Gene ID: 21687 | Gene type: protein coding

About Tek

Summary

Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of NIK/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tek Products(3)

mRNA	Protein	Name
NM_001290549.1	NP_001277478.1	angiopoietin-1 receptor isoform 2 precursor
NM_001290551.1	NP_001277480.1	angiopoietin-1 receptor isoform 3
NM_013690.3	NP_038718.2	angiopoietin-1 receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9204896	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7958865	MGI
enables signaling receptor activity	IPI IPI: Inferred from physical interaction	8980223	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	9846489	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	7596437	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	9683559	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9683559	MGI
involved in endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	7958865	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	7958865	MGI
involved in heart trabecula formation	IMP IMP: Inferred from mutant phenotype	7958865	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	9846489	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	19409199	MGI
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11375937	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7958865	MGI
acts upstream of or within positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	15260986	MGI
acts upstream of or within positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	20060382	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	19409199	MGI
acts upstream of or within positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	20060382	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20060382	MGI
acts upstream of or within regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	9683559	MGI
acts upstream of or within regulation of cell migration	IDA IDA: Inferred from direct assay	20060382	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	9683559	MGI
acts upstream of or within regulation of non-canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	20060382	MGI
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	18439490	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	7958865	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20060382	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiopoietin-1 receptor

endothelial tyrosine kinase	endothelial-specific receptor tyrosine kinase
p140 TEK	tunica interna endothelial cell kinase
tyrosine kinase with Ig and EGF homology domains-2	tyrosine-protein kinase receptor TEK
tyrosine-protein kinase receptor TIE-2

Recombinant Tek Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73436	TIE-2 Protein, Mouse (sf9, His-GST)	Q02858 (Q770-A1122)	≥95%
HY-P73437	TIE-2 Protein, Mouse (HEK293, Fc)	NP_038718.2 (A23-K744)	≥95%
HY-P73610	TIE-2 Protein, Mouse (HEK293, His)	B1AWS8 (A23-K744)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14355	TEK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tek	NCBI	NCBI:7010
Macaca fascicularis	Tek	NCBI	NCBI:102122204
Rattus norvegicus	Tek	NCBI	NCBI:89804
Macaca mulatta	Tek	NCBI	NCBI:707455

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