Tnfrsf1b - tumor necrosis factor receptor superfamily, member 1b Gene

Mus musculus

Also known as p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

Gene ID: 21938 | Gene type: protein coding

About Tnfrsf1b

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF Receptor Superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf1b Products(1)

mRNA	Protein	Name
NM_011610.3	NP_035740.2	tumor necrosis factor receptor superfamily member 1B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10747083	MGI
enables tumor necrosis factor receptor activity	IPI IPI: Inferred from physical interaction	1645445	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within RNA destabilization	IMP IMP: Inferred from mutant phenotype	11588035	MGI
involved in aortic valve development	IGI IGI: Inferred from genetic interaction	26491108	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9551933	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	7990930	MGI
involved in glial cell-neuron signaling	IMP IMP: Inferred from mutant phenotype	27147664	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	9551933	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	17242187	MGI
involved in negative regulation of cardiac muscle hypertrophy	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in negative regulation of extracellular matrix constituent secretion	IGI IGI: Inferred from genetic interaction	26491108	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	11588035	MGI
involved in negative regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	27147664	MGI
involved in positive regulation of apoptotic process involved in morphogenesis	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	27147664	MGI
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	27147664	MGI
involved in pulmonary valve development	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	28052249	MGI
involved in regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	28052249	MGI
involved in regulation of cytokine production involved in immune response	IGI IGI: Inferred from genetic interaction	28052249	MGI
involved in regulation of myelination	IGI IGI: Inferred from genetic interaction	28052249	MGI
involved in regulation of neuroinflammatory response	IGI IGI: Inferred from genetic interaction	28052249	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	10747083	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17010968	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 1B

TNF receptor beta chain	TNF-RII
TNFR-II	p75 TNFR
p80 TNF-alpha receptor	tumor necrosis factor receptor 2
tumor necrosis factor receptor type II

Recombinant Tnfrsf1b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70516	TNF RII/TNFRSF1B Protein, Mouse (HEK293, His)	P25119/NP_035740.2 (V23-G258)	≥95%
HY-P72420	TNF RII/TNFRSF1B Protein, Mouse (HEK293, His-Avi)	Q545P4 (V23-G258)	≥95%
HY-P76108	TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc)	P25119 (M1-G258)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14811	TNFRSF1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990994	Emunkitug	Inhibitor	/	Unkown
HY-P99782	Opinercept	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfrsf1b	NCBI	NCBI:7133
Macaca mulatta	Tnfrsf1b	NCBI	NCBI:715454

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