2. Gene
  3. OTUD1 - OTU deubiquitinase 1 Gene

OTUD1 - OTU deubiquitinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DUBA7; OTDC1

Gene ID: 220213 | Gene type: protein coding

About OTUD1

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,439,075-23,442,377 (from NCBI)

This gene has 1 transcript (splice variant), 156 orthologues and 5 paralogues.

Summary

Deubiquitinating Enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]

OTUD1 Products(1)

mRNA Protein Name
NM_001145373.3 NP_001138845.1 OTU domain-containing protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD1 Protein Structure

OTU

OTU: OTU-like cysteine protease (316 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 1

DUBA-7

Related Diseases

Diseases Alias
Acquired Hyperkeratosis

Acquired Keratoderma

Keratoderma - Acquired

Keratoderma, Acquired

Keratosis Blennorrhagica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09871 OTUD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OTUD1 VGNC VGNC:75685
Canis familiaris OTUD1 VGNC VGNC:44184
Mus musculus OTUD1 MGD MGI:1918448
Rattus norvegicus OTUD1 RGD RGD:1563344
Bos taurus OTUD1 VGNC VGNC:32493