Ywhae - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Gene

Mus musculus

Gene ID: 22627 | Gene type: protein coding

About Ywhae

Summary

Enables protein domain specific binding activity and protein Phosphatase binding activity. Acts upstream of or within several processes, including negative regulation of protein dephosphorylation; neuron migration; and pallium development. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Ywhae Products(1)

mRNA	Protein	Name
NM_009536.4	NP_033562.3	14-3-3 protein epsilon

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11585834	MGI
enables protein domain specific binding	IDA IDA: Inferred from direct assay	12446771	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23326474	MGI
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	12796778	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	12796778	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	12796778	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	12796778	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	12796778	MGI
acts upstream of or within protein targeting	IDA IDA: Inferred from direct assay	12446771	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23326474	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

14-3-3 protein epsilon

14-3-3 epsilon	14-3-3E
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

Recombinant Ywhae Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75549	14-3-3 epsilon Protein, Mouse (His)	P62259 (M1-Q255)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS15941	YWHAE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ywhae	NCBI	NCBI:7531

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