PLA2R1 - phospholipase A2 receptor 1 Gene

Homo sapiens

Also known as PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R

Gene ID: 22925 | Gene type: protein coding

About PLA2R1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:159,923,933-160,062,615 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 11.6), kidney (RPKM 5.9) and 16 other tissues.

Summary

This gene represents a Phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of Phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

PLA2R1 Products(3)

mRNA	Protein	Name
NM_001007267.3	NP_001007268.1	secretory phospholipase A2 receptor isoform 2 precursor
NM_001195641.2	NP_001182570.1	secretory phospholipase A2 receptor isoform 3 precursor
NM_007366.5	NP_031392.3	secretory phospholipase A2 receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipase binding	IPI IPI: Inferred from physical interaction	7721806	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	7721806	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in oxidative stress-induced premature senescence	IMP IMP: Inferred from mutant phenotype	19197340	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	19197340	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	15611272	GOA
involved in positive regulation of podocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	25335547	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19197340	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	7721806	GOA
involved in replicative senescence	IMP IMP: Inferred from mutant phenotype	19197340	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15611272	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12225974	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2R1 Protein Structure

fn2

Lectin_C

0
300
600
900
1200
1463 a.a.

Protein Preferred Names

Protein Names

secretory phospholipase A2 receptor

180 kDa secretory phospholipase A2 receptor

Related Diseases

Diseases

Alias

Membranous Nephropathy

Membranous Glomerulonephritis	Glomerulonephritis, Membranous
Idiopathic Membranous Nephropathy	Idiopathic Membranous Glomerulonephritis
MBNP	Membranous Nephropathy, Susceptibility To
Extramembranous Glomerulonephritis	Mgn
Membranous Gn	Primary Membranous Glomerulonephritis
Primary Membranous Nephropathy	Nephropathy Membranous

Igg4-Related Disease

Multifocal Fibrosclerosis	Igg4-Related Sclerosing Disease
Igg4-Related Systemic Disease	Immunoglobulin G4-Related Sclerosing Disease
Hyper-Igg4 Disease	Igg4-Associated Disease
Igg4-Positive Multiorgan Lymphoproliferative Syndrome	Igg4-Related Autoimmune Disease
Igg4-Related Systemic Sclerosing Disease	Igg4-Syndrome
Multifocal Idiopathic Fibrosclerosis	Systemic Igg4-Related Plasmacytic Syndrome
Systemic Igg4-Related Sclerosing Syndrome	Mediastinal Fibrosis, Familial
Retroperitoneal Fibrosis, Familial	Igg4-Rd

Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7
NPHS7	Nephrotic Syndrome Type 7
Ig-Mediated Membranoproliferative Glomerulonephritis	Ig-Mediated Mpgn
Immunoglobulin-Mediated Mpgn	Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis
Hemolytic Uremic Syndrome, Atypical 7	Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis
Hemolytic Uremic Syndrome With Dgke Deficiency	Hus With Dgke Deficiency
Hemolytic Uremic Syndrome Atypical 7	AHUS7
Nephrotic Syndrome 7	Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis

Glomerulonephritis

Bright'S Disease

Goodpasture Syndrome

Anti-Glomerular Basement Membrane Disease	Anti-Gbm Disease
Pulmonary Renal Syndrome	Anti-Glomerular Basement Membrane Antibody Disease
Glomerulonephritis - Pulmonary Hemorrhage	Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage
Anti-Gbm Syndrome	Goodpasture'S Syndrome
Anti-Basement Membrane Glomerulonephritis

Autoimmune Disease Of Urogenital Tract

Kimura Disease

Kimura'S Disease	Eosinophilic Lymphogranuloma
Eosinophilic Granuloma Of Soft Tissue	Eosinophilic Hyperplastic Lymphogranuloma
Eosinophilic Lymphofollicular Granuloma	Eosinophilic Lymphofolliculosis

Immunoglobulin Heavy Chain Amyloidosis

Ah Amyloidosis	Heavy Chain Amyloidosis
Amyloidosis Derived From Immunoglobulin Heavy Chain	Ig Heavy-Chain-Associated Amyloidosis

Crescentic Glomerulonephritis

Idiopathic Crescentic Glomerulonephritis

Acute Proliferative Glomerulonephritis

Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Bronchiectasis 3

Lipoid Nephrosis

Minimal Change Disease	Minimal Change Glomerulonephritis
Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis	Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome
Idiopathic Minimal Change Nephrotic Syndrome	Mcns
Minimal Change Glomerulopathy	Minimal Change Nephrotic Syndrome
Nephrotic Syndrome Minimal Change	Nephrosis, Lipoid
Glomerulonephritis, Minimal Change	Nephrotic Syndrome, Minimal Change

Rapidly Progressive Glomerulonephritis

Glomerulonephritis Rapidly Progressive

Idiopathic Crescentic Glomerulonephritis

Acute Diffuse Nephritis

Acute Diffuse Glomerulonephritis

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Proliferative Glomerulonephritis

Anti-Basement Membrane Glomerulonephritis

Anti-Gbm Glomerulonephritis

Interstitial Nephritis

Nephritis, Interstitial	Renal Tubulo-Interstitial Disease
Nephritis Interstitial	Nephritis, Tubulointerstitial

Immune-Complex Glomerulonephritis

Immune Complex Glomerulonephritis

Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative	Mesangial Proliferative Gn
Mesangioproliferative Glomerulonephritis	Glomerulonephritis Mesangial Proliferative

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10635	PLA2R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLA2R1	VGNC	VGNC:104550
Mus musculus	PLA2R1	MGD	MGI:102468
Rattus norvegicus	PLA2R1	RGD	RGD:1309777
Felis catus	PLA2R1	VGNC	VGNC:80306
Bos taurus	PLA2R1	VGNC	VGNC:32966
Canis familiaris	PLA2R1	VGNC	VGNC:44633

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