FOXF1 - forkhead box F1 Gene

Homo sapiens

Also known as FKHL5; ACDMPV; FREAC1

Gene ID: 2294 | Gene type: protein coding

About FOXF1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:86,510,527-86,515,422 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues, 42 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 22.1), urinary bladder (RPKM 21.5) and 12 other tissues.

Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

FOXF1 Products(1)

mRNA	Protein	Name
NM_001451.3	NP_001442.2	forkhead box protein F1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9769171	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8626802	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8626802	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in digestive tract development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in embryonic ectodermal digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in endocardial cushion development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in heart development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in lung development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in lung vasculature development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in midgut development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in pancreas development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8626802	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8626802	GOA
involved in respiratory tube development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in trachea development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in ureter development	IMP IMP: Inferred from mutant phenotype	19500772	GOA
involved in venous blood vessel development	IMP IMP: Inferred from mutant phenotype	19500772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXF1 Protein Structure

Forkhead

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

forkhead box protein F1

FREAC-1

FOXF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82936	FOXF1 Antibody (YA2681)	WB, ICC/IF, FC	Human

Related Diseases

Diseases

Alias

Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Alveolar Capillary Dysplasia	ACDMPV
Alveolar Capillary Dysplasia With Pulmonary Venous Misalignment	Congenital Alveolar Capillary Dysplasia
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins And Other Congenital Anomalies	Familial Persistent Pulmonary Hypertension Of The Newborn
Acd	Pulmonary Hypertension, Familial Persistent Of The Newborn
Acd/Mpv	Misalignment Of The Pulmonary Vessels
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Vessels	Dysplasia, Capillary, Alveolar, With Misalignment Of Pulmonary Veins
Persistent Fetal Circulation Syndrome

Idiopathic/Heritable Pulmonary Arterial Hypertension

Idiopathic And/Or Familial Pulmonary Arterial Hypertension

Atresia Of Urethra

Urethral Atresia

Vacterl Association

Vater Association

Vater Syndrome

Pyloric Stenosis, Infantile Hypertrophic, 5

IHPS5

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Pyloric Stenosis

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Anus, Imperforate

Imperforate Anus	Anorectal Malformation
Anal Atresia	Anorectal Malformations
Congenital Atresia Of Anus	Congenital Or Infantile Occlusion Of Anus
Anal Stenosis	Arm

Neonatal Respiratory Failure

Respiratory Failure Of Newborn	Inadequate Pulmonary Ventilation Of Newborn
Newborn Lung Insufficiency	Newborn Pulmonary Function Inadequate
Newborn Pulmonary Insufficiency	Newborn Respiration Failure
Newborn Respiratory Insufficiency	Respiratory Insufficiency Syndrome Of Newborn

Duodenal Atresia

Duodenal Stenosis

Familial Duodenal Atresia

Volvulus Of Midgut

Volvulus	Intestinal Volvulus
Intestinal Malrotation, Familial	Familial Intestinal Malrotation
Twist Of Intestine, Bowel, Or Colon

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Microphthalmia, Syndromic 3

MCOPS3	Aeg Syndrome
Microphthalmia And Esophageal Atresia Syndrome	Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia-Esophageal-Genital Syndrome	Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System
Syndromic Microphthalmia 3	Sox2 Anophthalmia Syndrome
Anophthalmia Clinical With Associated Anomalies	Anophthalmia Esophageal Genital Syndrome
Anophthalmia Microphthalmia Esophageal Atresia	Syndromic Microphthalmia Type 3
Sox2-Related Eye Disorders	Anophthalmia, Clinical, With Associated Anomalies
Syndromic Microphthalmia, Type 3	Microphthalmia, Syndromic, 3
Anophthalmia/Microphthalmia-Esophageal Atresia	Microphthalmia Syndromic, Type 3

Intestinal Atresia

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Tracheomalacia

Congenital Tracheomalacia	Congenital Major Airway Collapse
Tracheomalacia, Congenital	Type 1 Tracheomalacia

Hernia, Hiatus

Hiatal Hernia	Hiatus Hernia
Diaphragmatic - Hiatus -Hernia	Hernia, Hiatal

Tracheal Stenosis

Stenosis Of Trachea

Vacterl Association, X-Linked, With Or Without Hydrocephalus

VACTERLX	X-Linked Vacterl Association
Vacterl-H, X-Linked	Vacterl Association, X-Linked
Vacterl Association, X-Linked With Or Without Hydrocephalus	Vacterl Association X-Linked With Or Without Hydrocephalus
Vacterl Syndrome	Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies
X-Linked Vacterl-H	Vacterl Association
Vacterl Association With Hydrocephalus

Anus Disease

Anal Fissure	Ulcer Of Anus
Anus Diseases	Anal Disease
Anal Fissure And Fistula	Anal Ulcer
Fissure In Ano	Nontraumatic Tear Of Anus
Solitary Anal Ulcer	Abnormality Of The Anus
Anal Disorders	Ulcer Of Anus And Rectum
Solitary Ulcer Of Anus	Stercoral Ulcer Of Anus

Tracheal Disease

Tracheal Diseases	Tracheal Anomaly
Tracheal Disorders

Astigmatism

Feingold Syndrome 1

Feingold Syndrome	Oculodigitoesophagoduodenal Syndrome
Oded Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum	FGLDS1
Mmt Syndrome	Brunner-Winter Syndrome
Feingold Syndrome Type 1	Oded
Moded	Fglds
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome	Moded Syndrome
Oculo-Digito-Esophageal-Duodenal Syndrome	Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome
Microcephaly And Digital Abnormalities With Normal Intelligence	Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum
Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Oculo-Digito-Esophagoduodental Syndrome	Fs
Mmt	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome	Brunner-Winter Syndrome Type 1
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1	Fs1
Mmt Type 1	Moded Syndrome Type 1
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1	Oded Syndrome Type 1
Oculo-Digito-Esophageal-Duodenal Syndrome Type 1	Feingold Syndrome, Type 1

Rhabdomyosarcoma

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Rectal Disease

Rectal Diseases

Rectal Disorders

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Cdh	Congenital Diaphragmatic Defect
Hernia, Diaphragmatic	Dih
Hernia, Congenital Diaphragmatic	Hcd
Diaphragmatic Defect, Congenital	Diaphragm, Unilateral Agenesis Of
Hemidiaphragm, Agenesis Of	Diaphragmatic Hernia 1
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hernia, Diaphragmatic, Type 1	Hiatus Hernia
Oesophageal Hiatus Hernia	Paraoesophageal Hernia
Sliding Hiatus Hernia	Congenital Diaphragm Hernia
Congenital Diaphragm Defect With Hernia	Gross Congenital Diaphragm Defect

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05049	FOXF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FOXF1	RGD	RGD:1584229
Macaca mulatta	FOXF1	VGNC	VGNC:104726
Canis familiaris	FOXF1	VGNC	VGNC:40949
Bos taurus	FOXF1	VGNC	VGNC:29084
Felis catus	FOXF1	VGNC	VGNC:62332
Mus musculus	FOXF1	MGD	MGI:1347470