TMCC1 - transmembrane and coiled-coil domain family 1 Gene

Homo sapiens

Gene ID: 23023 | Gene type: protein coding

About TMCC1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:129,647,792-129,893,711 (from NCBI)

This gene has 17 transcripts (splice variants), 299 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 4.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC1 Products(16)

mRNA	Protein	Name
NM_001017395.5	NP_001017395.2	transmembrane and coiled-coil domains protein 1 isoform a
NM_001128224.3	NP_001121696.1	transmembrane and coiled-coil domains protein 1 isoform c
NM_001349263.2	NP_001336192.1	transmembrane and coiled-coil domains protein 1 isoform a
NM_001349264.2	NP_001336193.1	transmembrane and coiled-coil domains protein 1 isoform a
NM_001349265.2	NP_001336194.1	transmembrane and coiled-coil domains protein 1 isoform a
NM_001349266.2	NP_001336195.1	transmembrane and coiled-coil domains protein 1 isoform a
NM_001349268.2	NP_001336197.1	transmembrane and coiled-coil domains protein 1 isoform a
NM_001349269.2	NP_001336198.1	transmembrane and coiled-coil domains protein 1 isoform c
NM_001349270.2	NP_001336199.1	transmembrane and coiled-coil domains protein 1 isoform c
NM_001349271.2	NP_001336200.1	transmembrane and coiled-coil domains protein 1 isoform d
NM_001349272.1	NP_001336201.1	transmembrane and coiled-coil domains protein 1 isoform e
NM_001349273.2	NP_001336202.1	transmembrane and coiled-coil domains protein 1 isoform f
NM_001349274.2	NP_001336203.1	transmembrane and coiled-coil domains protein 1 isoform g
NM_001349275.2	NP_001336204.1	transmembrane and coiled-coil domains protein 1 isoform h
NM_001349276.2	NP_001336205.1	transmembrane and coiled-coil domains protein 1 isoform h
NM_015008.5	NP_055823.1	transmembrane and coiled-coil domains protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24454821	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24454821	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	24454821	GOA
involved in endosomal transport	IDA IDA: Inferred from direct assay	30220460	GOA
involved in endosome fission	IDA IDA: Inferred from direct assay	30220460	GOA
involved in endosome membrane tubulation	IDA IDA: Inferred from direct assay	30220460	GOA
involved in membrane fission	IDA IDA: Inferred from direct assay	30220460	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IMP IMP: Inferred from mutant phenotype	24454821	GOA
located in endoplasmic reticulum-endosome membrane contact site	IDA IDA: Inferred from direct assay	30220460	GOA
located in rough endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	24454821	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMCC1 Protein Structure

Tmemb_cc2

0
100
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300
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653 a.a.

Protein Preferred Names

Protein Names

transmembrane and coiled-coil domains protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14629	TMCC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMCC1	VGNC	VGNC:66239
Bos taurus	TMCC1	VGNC	VGNC:35925
Mus musculus	TMCC1	MGD	MGI:2442368
Macaca mulatta	TMCC1	VGNC	VGNC:79776
Rattus norvegicus	TMCC1	RGD	RGD:1311909
Canis familiaris	TMCC1	VGNC	VGNC:47428

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