2. Gene
  3. PDZRN3 - PDZ domain containing ring finger 3 Gene

PDZRN3 - PDZ domain containing ring finger 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LNX3; SEMCAP3; SEMACAP3

Gene ID: 23024 | Gene type: protein coding

About PDZRN3

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:73,382,431-73,624,941 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in ovary (RPKM 21.4), endometrium (RPKM 16.6) and 20 other tissues.

Summary

This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 Ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

PDZRN3 Products(5)

mRNA Protein Name
NM_001303139.2 NP_001290068.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2
NM_001303140.2 NP_001290069.1 E3 ubiquitin-protein ligase PDZRN3 isoform 3
NM_001303141.2 NP_001290070.1 E3 ubiquitin-protein ligase PDZRN3 isoform 4
NM_001303142.2 NP_001290071.1 E3 ubiquitin-protein ligase PDZRN3 isoform 5
NM_015009.3 NP_055824.1 E3 ubiquitin-protein ligase PDZRN3 isoform 1

PDZRN3 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (17 - 57)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (101 - 146)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (252 - 335)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (424 - 500)

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  • 1066 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase PDZRN3

RING-type E3 ubiquitin transferase PDZRN3

Related Diseases

Diseases Alias
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10307 PDZRN3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDZRN3 VGNC VGNC:81917
Mus musculus PDZRN3 MGD MGI:1933157
Rattus norvegicus PDZRN3 RGD RGD:1305250
Felis catus PDZRN3 VGNC VGNC:102656
Bos taurus PDZRN3 VGNC VGNC:32731
Macaca mulatta PDZRN3 VGNC VGNC:75820