2. Gene
  3. MYT1L - myelin transcription factor 1 like Gene

MYT1L - myelin transcription factor 1 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NZF1; MRD39; myT1-L; ZC2H2C2; ZC2HC4B

Gene ID: 23040 | Gene type: protein coding

About MYT1L

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:1,789,113-2,331,275 (from NCBI)

This gene has 70 transcripts (splice variants), 288 orthologues, 5 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 9.8) and testis (RPKM 1.0).

Summary

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]

MYT1L Products(10)

mRNA Protein Name
NM_001303052.2 NP_001289981.1 myelin transcription factor 1-like protein isoform 1
NM_001329844.2 NP_001316773.1 myelin transcription factor 1-like protein isoform 1
NM_001329845.1 NP_001316774.1 myelin transcription factor 1-like protein isoform 1
NM_001329846.3 NP_001316775.1 myelin transcription factor 1-like protein isoform 3
NM_001329847.2 NP_001316776.1 myelin transcription factor 1-like protein isoform 2
NM_001329848.1 NP_001316777.1 myelin transcription factor 1-like protein isoform 2
NM_001329849.3 NP_001316778.1 myelin transcription factor 1-like protein isoform 4
NM_001329851.3 NP_001316780.1 myelin transcription factor 1-like protein isoform 5
NM_001329852.3 NP_001316781.1 myelin transcription factor 1-like protein isoform 6
NM_015025.4 NP_055840.2 myelin transcription factor 1-like protein isoform 2

MYT1L Protein Structure

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (30 - 58)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (504 - 532)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (548 - 577)

MYT1

MYT1: Myelin transcription factor 1 (621 - 873)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (902 - 932)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (953 - 981)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (1005 - 1034)

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  • 1186 a.a.
Protein Preferred Names Protein Names

myelin transcription factor 1-like protein

neural zinc finger transcription factor 1

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 39

MRD39

Mental Retardation, Autosomal Dominant 39

Mental Retardation, Autosomal Dominant 39, And Obesity

Autosomal Dominant Intellectual Developmental Disorder 39

Autosomal Dominant Mental Retardation 39

Autosomal Dominant Non-Syndromic Intellectual Disability 39

Mental Retardation, Autosomal Dominant, Type 39
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Autosomal Dominant Non-Syndromic Intellectual Disability
Alternating Exotropia

Exotropia
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Neuropathy, Hereditary Sensory And Autonomic, Type Iii

Familial Dysautonomia

Riley-Day Syndrome

Dysautonomia, Familial

HSAN3

Hsan Iii

Fd

Hereditary Sensory And Autonomic Neuropathy Type Iii

Dys

Hereditary Sensory And Autonomic Neuropathy 3

Riley Day Syndrome

Familial Autonomic Nervous Dysfunction

Hereditary Sensory Autonomic Neuropathy Type Iii

Hsan 3

Hsn 3

Hereditary Sensory Neuropathy Type 3

Hsan Type Iii

Hsn-Iii

Hereditary Sensory And Autonomic Neuropathy Type 3

Neuropathy, Hereditary Sensory And Autonomic, 3

Hsn Iii

Dysautonomia Familial

Neuropathy, Sensory And Autonomic, Hereditary, Type Iii

Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08974 MYT1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MYT1L VGNC VGNC:43592
Bos taurus MYT1L VGNC VGNC:59198
Mus musculus MYT1L MGD MGI:1100511
Rattus norvegicus MYT1L RGD RGD:620550
Macaca mulatta MYT1L VGNC VGNC:99698