TRIM35 - tripartite motif containing 35 Gene

Homo sapiens

Also known as HLS5; MAIR

Gene ID: 23087 | Gene type: protein coding

About TRIM35

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,284,886-27,311,272 (from NCBI)

This gene has 4 transcripts (splice variants), 121 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

TRIM35 Products(3)

mRNA	Protein	Name
NM_001304495.2	NP_001291424.1	E3 ubiquitin-protein ligase TRIM35 isoform 2
NM_001362813.2	NP_001349742.1	E3 ubiquitin-protein ligase TRIM35 isoform 3
NM_171982.5	NP_741983.2	E3 ubiquitin-protein ligase TRIM35 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	14662771	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	14662771	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM35 Protein Structure

zf-C3HC4_2

zf-B_box

PRY

SPRY

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM35

hemopoietic lineage switch protein 5

Related Diseases

Diseases

Alias

Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases	Telangiectatic Membranoproliferative Glomerulonephritis
HLTRS	Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome
Hlt-Renal Defect Syndrome	Glomerulonephritis Sparse Hair Telangiectases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15039	TRIM35 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM35	VGNC	VGNC:79026
Rattus norvegicus	TRIM35	RGD	RGD:1564642
Felis catus	TRIM35	VGNC	VGNC:66535
Canis familiaris	TRIM35	VGNC	VGNC:47816
Mus musculus	TRIM35	MGD	MGI:1914104
Bos taurus	TRIM35	VGNC	VGNC:36330

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