2. Gene
  3. TRIM35 - tripartite motif containing 35 Gene

TRIM35 - tripartite motif containing 35 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HLS5; MAIR

Gene ID: 23087 | Gene type: protein coding

About TRIM35

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,284,886-27,311,272 (from NCBI)

This gene has 4 transcripts (splice variants), 121 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

TRIM35 Products(3)

mRNA Protein Name
NM_001304495.2 NP_001291424.1 E3 ubiquitin-protein ligase TRIM35 isoform 2
NM_001362813.2 NP_001349742.1 E3 ubiquitin-protein ligase TRIM35 isoform 3
NM_171982.5 NP_741983.2 E3 ubiquitin-protein ligase TRIM35 isoform 1

TRIM35 Protein Structure

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (21 - 60)

zf-B_box

zf-B_box: B-box zinc finger (99 - 137)

PRY

PRY: SPRY-associated domain (305 - 351)

SPRY

SPRY: SPRY domain (353 - 468)

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  • 493 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM35

hemopoietic lineage switch protein 5

Related Diseases

Diseases Alias
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15039 TRIM35 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM35 VGNC VGNC:79026
Rattus norvegicus TRIM35 RGD RGD:1564642
Felis catus TRIM35 VGNC VGNC:66535
Canis familiaris TRIM35 VGNC VGNC:47816
Mus musculus TRIM35 MGD MGI:1914104
Bos taurus TRIM35 VGNC VGNC:36330