TUT4 - terminal uridylyl transferase 4 Gene

Homo sapiens

Also known as PAPD3; TENT3A; ZCCHC11

Gene ID: 23318 | Gene type: protein coding

About TUT4

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,423,275-52,553,463 (from NCBI)

This gene has 21 transcripts (splice variants), 257 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.1), thyroid (RPKM 9.7) and 25 other tissues.

Summary

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

TUT4 Products(2)

mRNA	Protein	Name
NM_001009881.3	NP_001009881.1	terminal uridylyltransferase 4 isoform a
NM_015269.2	NP_056084.1	terminal uridylyltransferase 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA uridylyltransferase activity	IDA IDA: Inferred from direct assay	19703396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16643855	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA 3'-end processing	IDA IDA: Inferred from direct assay	19703396	GOA
NOT involved in histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	18172165	GOA
involved in miRNA catabolic process	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in miRNA metabolic process	IDA IDA: Inferred from direct assay	25979828	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	25979828	GOA
involved in pre-miRNA processing	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in retrotransposon silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	30122351	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19703396	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19703396	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	30122351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUT4 Protein Structure

PAP_assoc

NTP_transf_2

PAP_assoc

zf-CCHC

0
300
600
900
1200
1500
1644 a.a.

Protein Preferred Names

Protein Names

terminal uridylyltransferase 4

PAP associated domain containing 3

Related Diseases

Diseases

Alias

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Trichothiodystrophy 1, Photosensitive

TTD1	Tay Syndrome
Trichothiodystrophy With Congenital Ichthyosis	Photosensitive Trichothiodystrophy
Ibids Syndrome	Ttdp
Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation	Ichthyosis, Congenital, With Trichothiodystrophy
Pibids Syndrome	Photosensitive Trichothiodystrophy 1
Trichothiodystrophy, Photosensitive	Sulfur-Deficient Brittle Hair Syndrome
Ttd-P	Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature
Trichothiodystrophy Photosensitive	Trichothiodystrophy, Type 1
Tricho-Thiodystrophy Disorder	Trichothiodystrophy Syndromes
Amish Brittle Hair Brain Syndrome

Trichothiodystrophy 6, Nonphotosensitive

TTD6	Nonphotosensitive Trichothiodystrophy 6
Trichothiodystrophy 6, Non-Photosensitive

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor	Nonanaplastic Renal Wilm'S Tumour
Nonanaplastic Renal Wilms Tumor	Renal Wilms' Tumour

Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome

Spastic Ataxia 4

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169090	TS-002902	Inhibitor	/	Unkown
HY-169091	TS-002266	Inhibitor	/	Unkown
HY-RS15277	TUT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TUT4	VGNC	VGNC:48566
Bos taurus	TUT4	VGNC	VGNC:37116
Felis catus	TUT4	VGNC	VGNC:66714
Mus musculus	TUT4	MGD	MGI:2445126
Macaca mulatta	TUT4	VGNC	VGNC:79759
Rattus norvegicus	TUT4	RGD	RGD:1310138

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