2. Gene
  3. TTC28 - tetratricopeptide repeat domain 28 Gene

TTC28 - tetratricopeptide repeat domain 28 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TPRBK

Gene ID: 23331 | Gene type: protein coding

About TTC28

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:27,978,014-28,679,840 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.6) and 24 other tissues.

Summary

Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody. [provided by Alliance of Genome Resources, Apr 2022]

TTC28 Products(4)

mRNA Protein Name
NM_001145418.2 NP_001138890.1 tetratricopeptide repeat protein 28 isoform 1
NM_001393403.1 NP_001380332.1 tetratricopeptide repeat protein 28 isoform 2
NM_001393404.1 NP_001380333.1 tetratricopeptide repeat protein 28 isoform 3
NM_001393405.1 NP_001380334.1 tetratricopeptide repeat protein 28 isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase binding IPI
IPI: Inferred from physical interaction
23036704 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23036704 GOA
Cellular Component GO Annotation Evidence Reference Source
located in midbody IDA
IDA: Inferred from direct assay
23036704 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC28 Protein Structure

TPR_11

TPR_11: TPR repeat (63 - 123)

TPR_2

TPR_2: Tetratricopeptide repeat (126 - 158)

TPR_7

TPR_7: Tetratricopeptide repeat (276 - 309)

TPR_12

TPR_12: Tetratricopeptide repeat (315 - 385)

TPR_1

TPR_1: Tetratricopeptide repeat (394 - 425)

TPR_12

TPR_12: Tetratricopeptide repeat (477 - 543)

TPR_12

TPR_12: Tetratricopeptide repeat (553 - 625)

TPR_2

TPR_2: Tetratricopeptide repeat (635 - 666)

TPR_1

TPR_1: Tetratricopeptide repeat (674 - 696)

TPR_10

TPR_10: Tetratricopeptide repeat (754 - 787)

TPR_1

TPR_1: Tetratricopeptide repeat (795 - 819)

TPR_12

TPR_12: Tetratricopeptide repeat (833 - 908)

TPR_12

TPR_12: Tetratricopeptide repeat (956 - 1021)

TPR_12

TPR_12: Tetratricopeptide repeat (1037 - 1109)

CHAT

CHAT: CHAT domain (1391 - 1713)

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  • 2481 a.a.
Protein Preferred Names Protein Names

tetratricopeptide repeat protein 28

TPR repeat protein 28

Related Diseases

Diseases Alias
Ankyloglossia With Or Without Tooth Anomalies

Ankyloglossia

ANKG

'Tongue-Tie'

Tongue-Tie

Tongue Tie

Aberrant Insertion Of Labial Frenulum

Aberrant Insertion Of Frenum Of Tongue

Short Frenulum Linguae

Short Frenulum Of Tongue
Cleft Soft Palate

Cleft Velum

Cleft Velum Palatinum

Soft Cleft Palate

Soft Palate Perforation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15206 TTC28 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TTC28 VGNC VGNC:66664
Rattus norvegicus TTC28 RGD RGD:1594541
Macaca mulatta TTC28 VGNC VGNC:79785
Bos taurus TTC28 VGNC VGNC:36467
Mus musculus TTC28 MGD MGI:2140873
Canis familiaris TTC28 VGNC VGNC:47948