SEZ6L - seizure related 6 homolog like Gene

Homo sapiens

Gene ID: 23544 | Gene type: protein coding

About SEZ6L

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:26,169,462-26,383,596 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 39 paralogues. Biased expression in brain (RPKM 35.1) and adrenal (RPKM 5.4).

Summary

Predicted to act upstream of or within adult locomotory behavior; nervous system development; and regulation of protein kinase C signaling. Predicted to be located in endoplasmic reticulum and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SEZ6L Products(6)

mRNA	Protein	Name
NM_001184773.2	NP_001171702.1	seizure 6-like protein isoform 2 precursor
NM_001184774.2	NP_001171703.1	seizure 6-like protein isoform 3 precursor
NM_001184775.2	NP_001171704.1	seizure 6-like protein isoform 4 precursor
NM_001184776.2	NP_001171705.1	seizure 6-like protein isoform 5 precursor
NM_001184777.2	NP_001171706.1	seizure 6-like protein isoform 6 precursor
NM_021115.5	NP_066938.2	seizure 6-like protein isoform 1 precursor

SEZ6L Protein Structure

CUB

Sushi

CUB

Sushi

CUB

Sushi

0
200
400
600
800
1024 a.a.

Protein Preferred Names

Protein Names

seizure 6-like protein

seizure related gene 6-like

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12754	SEZ6L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12755	SEZ6L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SEZ6L	MGD	MGI:1935121
Macaca mulatta	SEZ6L	VGNC	VGNC:77176
Canis familiaris	SEZ6L	VGNC	VGNC:46064
Felis catus	SEZ6L	VGNC	VGNC:65050
Bos taurus	SEZ6L	VGNC	VGNC:34503
Rattus norvegicus	SEZ6L	RGD	RGD:1563628
Others	SEZ6L	NCBI

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