ZMYND8 - zinc finger MYND-type containing 8 Gene

Homo sapiens

Also known as RACK7; PRKCBP1; PRO2893

Gene ID: 23613 | Gene type: protein coding

About ZMYND8

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:47,209,214-47,356,699 (from NCBI)

This gene has 21 transcripts (splice variants), 281 orthologues and 5 paralogues. Ubiquitous expression in adrenal (RPKM 6.9), testis (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZMYND8 Products(20)

mRNA	Protein	Name
NM_001281769.2	NP_001268698.1	protein kinase C-binding protein 1 isoform d
NM_001281771.3	NP_001268700.1	protein kinase C-binding protein 1 isoform e
NM_001281772.3	NP_001268701.1	protein kinase C-binding protein 1 isoform f
NM_001281773.3	NP_001268702.1	protein kinase C-binding protein 1 isoform g
NM_001281774.3	NP_001268703.1	protein kinase C-binding protein 1 isoform h
NM_001281775.3	NP_001268704.1	protein kinase C-binding protein 1 isoform i
NM_001281776.3	NP_001268705.1	protein kinase C-binding protein 1 isoform j
NM_001281777.3	NP_001268706.1	protein kinase C-binding protein 1 isoform k
NM_001281778.3	NP_001268707.1	protein kinase C-binding protein 1 isoform l
NM_001281779.3	NP_001268708.1	protein kinase C-binding protein 1 isoform m
NM_001281780.3	NP_001268709.1	protein kinase C-binding protein 1 isoform n
NM_001281781.3	NP_001268710.1	protein kinase C-binding protein 1 isoform o
NM_001281782.3	NP_001268711.1	protein kinase C-binding protein 1 isoform p
NM_001281783.3	NP_001268712.1	protein kinase C-binding protein 1 isoform q
NM_001281784.3	NP_001268713.1	protein kinase C-binding protein 1 isoform r
NM_001363714.1	NP_001350643.1	protein kinase C-binding protein 1 isoform s
NM_001363741.2	NP_001350670.1	protein kinase C-binding protein 1 isoform t
NM_012408.6	NP_036540.3	protein kinase C-binding protein 1 isoform b
NM_183047.4	NP_898868.1	protein kinase C-binding protein 1 isoform a
NM_183048.4	NP_898869.1	protein kinase C-binding protein 1 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	27477906	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	27477906	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15095401	GOA
enables protein domain specific binding	IDA IDA: Inferred from direct assay	28966017	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	27477906	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	28966017	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	25593309	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27477906	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25593309	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	35916866	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26655721	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IPI IPI: Inferred from physical interaction	30134174	GOA
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	25593309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	25593309	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	28966017	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27477906	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYND8 Protein Structure

PHD

Bromodomain

PWWP

DUF3544

zf-MYND

0
200
400
600
800
1000
1186 a.a.

Protein Preferred Names

Protein Names

protein kinase C-binding protein 1

CTCL tumor antigen se14-3

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16096	ZMYND8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZMYND8	RGD	RGD:1309544
Canis familiaris	ZMYND8	VGNC	VGNC:48654
Felis catus	ZMYND8	VGNC	VGNC:83481
Mus musculus	ZMYND8	MGD	MGI:1918025
Macaca mulatta	ZMYND8	VGNC	VGNC:98468
Bos taurus	ZMYND8	VGNC	VGNC:37206

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