2. Gene
  3. Tnfsf13b - tumor necrosis factor (ligand) superfamily, member 13b Gene

Tnfsf13b - tumor necrosis factor (ligand) superfamily, member 13b Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; Tnlg7a; TNFSF20; D8Ertd387e

Gene ID: 24099 | Gene type: protein coding

About Tnfsf13b

Summary

Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF Superfamily member 13b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf13b Products(2)

mRNA Protein Name
NM_001347309.1 NP_001334238.1 tumor necrosis factor ligand superfamily member 13B isoform 2
NM_033622.2 NP_296371.1 tumor necrosis factor ligand superfamily member 13B isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell costimulation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
17581616 MGI
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
18624351 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
17581616 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of germinal center formation IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within immunoglobulin production IGI
IGI: Inferred from genetic interaction
15485634 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within positive regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of or within transitional one stage B cell differentiation IMP
IMP: Inferred from mutant phenotype
17581616 MGI
involved in tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
18624351 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 13B

b cell-activating factor

tumor necrosis factor ligand 7a

Recombinant Tnfsf13b Proteins

Cat. No. Product Name Accession Purity
HY-P70816 BAFF/TNFSF13B Protein, Mouse (HEK293, Fc) Q9WU72-1 (A127-L309) ≥95%
HY-P700161AF Animal-Free BAFF/TNFSF13B Protein, Mouse (His) Q9WU72 (A127-L309) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14824 TNFSF13B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf13b NCBI NCBI:10673
Canis familiaris Tnfsf13b NCBI NCBI:485545
Macaca fascicularis Tnfsf13b NCBI NCBI:102123214
Macaca mulatta Tnfsf13b NCBI NCBI:693917