2. Gene
  3. Cad - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Gene

Cad - carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24240 | Gene type: protein coding

About Cad

Summary

Enables several functions, including aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in several processes, including alpha-amino acid metabolic process; animal organ development; and pyrimidine-containing compound biosynthetic process. Located in cytosol; neuronal cell body; and terminal bouton. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Apr 2022]

Cad Products(1)

mRNA Protein Name
NM_001105710.2 NP_001099180.2 CAD protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aspartate carbamoyltransferase activity IDA
IDA: Inferred from direct assay
1148171 RGD
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
IDA: Inferred from direct assay
1148171 RGD
enables dihydroorotase activity IDA
IDA: Inferred from direct assay
1148171 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
26565 RGD
Biological Process GO Annotation Evidence Reference Source
involved in 'de novo' pyrimidine nucleobase biosynthetic process IDA
IDA: Inferred from direct assay
1476792 RGD
involved in UTP biosynthetic process IDA
IDA: Inferred from direct assay
10659854 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
13671431 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
10659854 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
8548770 RGD
involved in citrulline biosynthetic process IDA
IDA: Inferred from direct assay
7053379 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
6020217 RGD
involved in glutamine metabolic process IDA
IDA: Inferred from direct assay
2803258 RGD
involved in glutamine metabolic process IEP
IEP: Inferred from expression pattern
2474281 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
14160653 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
1476792 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
14160653 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
2864015 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
6149265 RGD
involved in response to cortisol IEP
IEP: Inferred from expression pattern
2353918 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
3311028 RGD
involved in response to starvation IDA
IDA: Inferred from direct assay
3311028 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
6030068 RGD
involved in xenobiotic metabolic process IMP
IMP: Inferred from mutant phenotype
18515330 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell projection IDA
IDA: Inferred from direct assay
1673139 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
1673139 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
26565 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
1673139 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CAD protein

carbamyl phosphatate synthetase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109160 Rimtuzalcap Activator 99.41% Yes
HY-139580 Plazinemdor Agonist 98.68% Unkown
HY-123494 BRD0418 Modulator / Unkown
HY-124609 CAD031 Inhibitor 99.39% Unkown
HY-44809A Izilendustat hydrochloride Inhibitor / Unkown
HY-103406 PNU-177864 / Unkown
HY-103406A PNU-177864 hydrochloride / Unkown
HY-128912 Arborinine Inhibitor / Unkown
HY-RS01818 CAD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-128446 CAY10781 Inhibitor / Unkown
HY-164466 CAD204520 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cad NCBI NCBI:790
Macaca fascicularis Cad NCBI NCBI:102128048
Mus musculus Cad NCBI NCBI:69719
Susscrofa domestica Cad NCBI
Macaca mulatta Cad NCBI NCBI:699460