Gck - glucokinase Gene

Rattus norvegicus

Also known as GLK; GLUKA; RNGK2

Gene ID: 24385 | Gene type: protein coding

About Gck

Primary_assembly 14: 80,785,060-80,826,995 reverse strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 29 phenotypes. Biased expression in Liver (RPKM 79.4) and Heart (RPKM 6.).

Summary

Enables several functions, including adenyl ribonucleotide binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to hormone stimulus; and hexose metabolic process. Located in several cellular components, including basal cortex; nucleoplasm; and secretory granule. Colocalizes with actin filament. Used to study fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products(3)

mRNA	Protein	Name
NM_001270849.1	NP_001257778.1	hexokinase-4 isoform 1
NM_001270850.1	NP_001257779.1	hexokinase-4 isoform 3
NM_012565.2	NP_036697.1	hexokinase-4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	12513690	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	12513690	RGD
enables D-glucose binding	IDA IDA: Inferred from direct assay	4273555	RGD
enables D-glucose binding	IPI IPI: Inferred from physical interaction	12513690	RGD
enables fructokinase activity	IDA IDA: Inferred from direct assay	6477520	RGD
enables glucokinase activity	IDA IDA: Inferred from direct assay	4273555	RGD
enables glucose sensor activity	IDA IDA: Inferred from direct assay	17470517	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12513690	RGD
enables mannokinase activity	IDA IDA: Inferred from direct assay	7742312	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10601273	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10913113	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	9109397	RGD
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	18292346	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	17470517	RGD
involved in cellular response to leptin stimulus	IDA IDA: Inferred from direct assay	17470517	RGD
involved in fructose 2,6-bisphosphate metabolic process	IDA IDA: Inferred from direct assay	17553851	RGD
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	6477520	RGD
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	4273555	RGD
involved in glucose metabolic process	IDA IDA: Inferred from direct assay	17553851	RGD
involved in glycogen biosynthetic process	IDA IDA: Inferred from direct assay	17028192	RGD
involved in glycolytic process	IDA IDA: Inferred from direct assay	4273555	RGD
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16443775	RGD
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	22925001	RGD
involved in mannose metabolic process	IDA IDA: Inferred from direct assay	7742312	RGD
involved in negative regulation of epinephrine secretion	IMP IMP: Inferred from mutant phenotype	18292346	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	17360975	RGD
involved in positive regulation of glycolytic process	IDA IDA: Inferred from direct assay	17553851	RGD
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	17028192	RGD
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	17553851	RGD
involved in regulation of glucose mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16443775	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	17470517	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12086933	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	9109397	RGD
located in basal cortex	IDA IDA: Inferred from direct assay	10071239	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	12369705	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10601273	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	12369705	RGD
located in nucleus	IDA IDA: Inferred from direct assay	10601273	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	9357983	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gck Protein Structure

Hexokinase_1

Hexokinase_2

0
100
200
300
400
498 a.a.

Protein Preferred Names

Protein Names

hexokinase-4

HK IV	HK4
hexokinase type IV	hexokinase-D

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147141	HS-276	Inhibitor	98.59%	Unkown
HY-15489	Scriptaid		98.59%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-123714	TL4-12		99.82%	Unkown
HY-170365	HPK1-IN-55	Inhibitor	/	Unkown
HY-RS05329	GCK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05330	Gck Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05331	Gck Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gck	NCBI	NCBI:2645

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