Il1a - interleukin 1 alpha Gene

Rattus norvegicus

Also known as IL-1F1; IL-1 alpha

Gene ID: 24493 | Gene type: protein coding

About Il1a

Primary_assembly 3: 116,526,604-116,536,822 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 92 orthologues and is associated with 116 phenotypes. Biased expression in Liver (RPKM 64.8), Lung (RPKM 41.1) and 6 other tissues.

Summary

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il1a Products(1)

mRNA	Protein	Name
NM_017019.2	NP_058715.1	interleukin-1 alpha

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in heart development	IEP IEP: Inferred from expression pattern	1297459	RGD
involved in keratinization	IDA IDA: Inferred from direct assay	20385541	RGD
involved in negative regulation of establishment of Sertoli cell barrier	IDA IDA: Inferred from direct assay	18057314	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16595703	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15671867	RGD
acts upstream of positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	31172560	RGD
acts upstream of positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	31172560	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17621543	RGD
involved in positive regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	1826836	RGD
involved in positive regulation of prostaglandin secretion	IDA IDA: Inferred from direct assay	8612624	RGD
involved in positive regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	16595703	RGD
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	15671867	RGD
acts upstream of positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	31172560	RGD
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	18057314	RGD
involved in response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	18983910	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	16524844	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15197744	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19524137	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16087301	RGD
involved in response to ozone	IEP IEP: Inferred from expression pattern	17901407	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	7859917	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	17621543	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12270120	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1a Protein Structure

IL1_propep

IL1

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

interleukin-1 alpha

Recombinant Il1a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7096	IL-1 alpha Protein, Rat (CHO)	P16598 (A116-S270)	≥95%
HY-P72572	IL-1 alpha Protein, Rat	P16598 (S115-S270)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4542	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)	Antagonist	/	Unkown
HY-RS06713	IL1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06714	Il1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06715	Il1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99138	Anti-Mouse IL-1a Antibody (ALF-161)	Inhibitor	≥95.0%	Unkown
HY-P991008	Lunlekitug	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1a	NCBI	NCBI:3552
Macaca fascicularis	Il1a	NCBI	NCBI:101926546
Mus musculus	Il1a	NCBI	NCBI:16175
Susscrofa domestica	Il1a	NCBI
Macaca mulatta	Il1a	NCBI	NCBI:700193

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