1. Gene
  2. Neto1 - neuropilin (NRP) and tolloid (TLL)-like 1 Gene

Neto1 - neuropilin (NRP) and tolloid (TLL)-like 1 Gene

Mus musculus

Also known as Btcl1; C130005O10Rik

Gene ID: 246317 | Gene type: protein coding

About Neto1

Summary

Enables ionotropic glutamate receptor binding activity. Involved in memory; regulation of long-term neuronal synaptic plasticity; and visual learning. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located in excitatory synapse and postsynaptic density membrane. Is integral component of postsynaptic density membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; metencephalon lateral wall; and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Apr 2022]

Neto1 Products(2)

mRNA Protein Name
NM_001360910.1 NP_001347839.1 neuropilin and tolloid-like protein 1 isoform 2
NM_144946.5 NP_659195.3 neuropilin and tolloid-like protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
21734292 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19243221 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
28680963 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
28680963 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
19243221 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
19243221 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19243221 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
19243221 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19243221 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
19243221 MGI
is active in postsynaptic density membrane EXP
EXP: Inferred from Experiment
19243221 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
19243221 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
19243221 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
19243221 MGI
located in synapse IDA
IDA: Inferred from direct assay
21734292 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuropilin and tolloid-like protein 1

brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

Neto1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Neto1 Q8R4I7 Dlg4 Mus musculus Q62108
Y2H
19243221
Intra
Neto1 Q8R4I7 Dlg4 Mus musculus Q62108 19243221
Cross
Neto1 Q8R4I7 DLG4 Homo sapiens P78352 19243221
Cross
Neto1 Q8R4I7 Grin2b Rattus norvegicus Q00960 19243221
Cross
Neto1 Q8R4I7 Grin2a Rattus norvegicus Q00959 19243221
Cross
Neto1 Q8R4I7 Grin2a Rattus norvegicus Q00959 19243221
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Neto1 NCBI NCBI:81832