Reg1a - regenerating family member 1 alpha Gene

Rattus norvegicus

Also known as Reg; RGPI; Reg1; Rgp1; LITHOST; RATRGPI; RATLITHOST

Gene ID: 24714 | Gene type: protein coding

About Reg1a

Summary

Enables growth factor activity; identical protein binding activity; and protein Phosphatase binding activity. Involved in several processes, including animal organ regeneration; cellular response to gastrin; and positive regulation of epithelial cell proliferation. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and zymogen granule. Part of protein-containing complex. Biomarker of colon Cancer and myocardial infarction. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Reg1a Products(1)

mRNA	Protein	Name
NM_012641.2	NP_036773.1	lithostathine precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	10526060	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11278730	RGD
enables phosphatase binding	IPI IPI: Inferred from physical interaction	18929742	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10662590	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	18929742	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10753861	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to chemokine	IEP IEP: Inferred from expression pattern	11113082	RGD
involved in cellular response to gastrin	IEP IEP: Inferred from expression pattern	10348814	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	19284990	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	7720628	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18929742	RGD
involved in pancreas regeneration	IEP IEP: Inferred from expression pattern	1985964	RGD
involved in positive regulation of acinar cell proliferation	IDA IDA: Inferred from direct assay	9788538	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	22158612	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18929742	RGD
involved in positive regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	24055447	RGD
involved in response to gastrin	IEP IEP: Inferred from expression pattern	9834276	RGD
involved in response to growth hormone-releasing hormone	IEP IEP: Inferred from expression pattern	7720628	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	24055447	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	1985964	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16874863	RGD
involved in response to water-immersion restraint stress	IEP IEP: Inferred from expression pattern	8698224	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal part of cell	IDA IDA: Inferred from direct assay	12764608	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	22158612	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	1886885	RGD
located in growth cone	IDA IDA: Inferred from direct assay	22158612	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	22158612	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22158612	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11278730	RGD
located in zymogen granule	IDA IDA: Inferred from direct assay	12764608	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lithostathine

ICRF	PSP
PTP	islet cells regeneration factor
islet of Langerhans regenerating protein	pancreatic stone protein
pancreatic thread protein	regenerating islet-derived 1 alpha
regenerating islet-derived mouse homolog 1	regeneration protein, lithostat

Recombinant Reg1a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77173	REG1A Protein, Rat (HEK293, Fc)	P10758 (Q22-A165)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11818	REG1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Reg1a	NCBI	NCBI:5967
Macaca fascicularis	Reg1a	NCBI

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