2. Gene
  3. Drd5 - dopamine receptor D5 Gene

Drd5 - dopamine receptor D5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as D1B

Gene ID: 25195 | Gene type: protein coding

About Drd5

Primary_assembly 14: 72,489,347-72,490,774 reverse strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 190 orthologues, 35 paralogues and is associated with 12 phenotypes.

Summary

Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating Dopamine Receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (Dopamine Receptor D5). [provided by Alliance of Genome Resources, Apr 2022]

Drd5 Products(1)

mRNA Protein Name
NM_012768.2 NP_036900.2 D(1B) dopamine receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
12623966 RGD
enables dopamine neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
1831904 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19465068 RGD
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
1831904 RGD
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
1831904 RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12688394 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
12688394 RGD
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
12688394 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: Inferred from Experiment
16914681 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
16914681 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
16914681 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
17142305 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
16175554 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
12623966 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16175554 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
21749912 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16914681 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16914681 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21749912 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
21749912 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

D(1B) dopamine receptor

d(5) dopamine receptor

dopamine D5 receptor

dopamine receptor 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04006 DRD5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04007 Drd5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04008 Drd5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd5 NCBI NCBI:1816