Cnr1 - cannabinoid receptor 1 Gene

Rattus norvegicus

Also known as SKR6R

Gene ID: 25248 | Gene type: protein coding

About Cnr1

Primary_assembly 5: 48,408,574-48,435,099 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 206 orthologues, 18 paralogues and is associated with 57 phenotypes. Biased expression in Brain (RPKM 374.6), Adrenal (RPKM 99.1) and 2 other tissues.

Summary

Enables Cannabinoid Receptor activity. Involved in several processes, including positive regulation of acute inflammatory response; regulation of secretion by cell; and response to alkaloid. Located in membrane raft and plasma membrane. Colocalizes with intracellular membrane-bounded organelle. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnr1 Products(1)

mRNA	Protein	Name
NM_012784.5	NP_036916.1	cannabinoid receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cannabinoid receptor activity	IMP IMP: Inferred from mutant phenotype	2165569	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17356572	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	2165569	RGD
involved in cannabinoid signaling pathway	IDA IDA: Inferred from direct assay	17895407	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	19880592	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	19860893	RGD
involved in memory	IDA IDA: Inferred from direct assay	19666083	RGD
involved in negative regulation of action potential	IMP IMP: Inferred from mutant phenotype	20067581	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19295473	RGD
involved in negative regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	19187091	RGD
involved in negative regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	19724020	RGD
involved in negative regulation of mast cell activation	IDA IDA: Inferred from direct assay	18552882	RGD
involved in negative regulation of monoatomic ion transport	IDA IDA: Inferred from direct assay	19463903	RGD
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	18561998	RGD
involved in negative regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	30217553	RGD
involved in positive regulation of acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	19282305	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19560819	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19553924	RGD
involved in positive regulation of fever generation	IMP IMP: Inferred from mutant phenotype	19681872	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19861414	RGD
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	19575185	RGD
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19644453	RGD
involved in regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	19325539	RGD
involved in regulation of penile erection	IMP IMP: Inferred from mutant phenotype	17850365	RGD
involved in regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	19725112	RGD
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	19725112	RGD
involved in response to cocaine	IMP IMP: Inferred from mutant phenotype	19401177	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	19860799	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19295473	RGD
involved in response to nicotine	IMP IMP: Inferred from mutant phenotype	19463710	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19807847	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	18614700	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	21895628	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17895407	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cnr1 Protein Structure

7tmA_CB1

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

cannabinoid receptor 1

CB-R	CB1
brain-type cannabinoid receptor	cannabinoid receptor 1 (brain)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02914	CNR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02915	Cnr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02916	Cnr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnr1	NCBI	NCBI:1268

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