HEPACAM2 - HEPACAM family member 2 Gene

Homo sapiens

Also known as MIKI

Gene ID: 253012 | Gene type: protein coding

About HEPACAM2

Cytogenetic location: 7q21.2 Genomic coordinates (GRCh38): 7:93,188,534-93,232,285 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 24 paralogues. Biased expression in colon (RPKM 38.5), small intestine (RPKM 21.6) and 3 other tissues.

Summary

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and Apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]

HEPACAM2 Products(5)

mRNA	Protein	Name
NM_001039372.4	NP_001034461.1	HEPACAM family member 2 isoform 1 precursor
NM_001288804.3	NP_001275733.1	HEPACAM family member 2 isoform 3
NM_001288810.3	NP_001275739.1	HEPACAM family member 2 isoform 4 precursor
NM_001346642.2	NP_001333571.1	HEPACAM family member 2 isoform 5
NM_198151.4	NP_937794.1	HEPACAM family member 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22864114	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	22864114	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	22864114	GOA
located in centrosome	IDA IDA: Inferred from direct assay	22864114	GOA
located in midbody	IDA IDA: Inferred from direct assay	22864114	GOA
located in spindle	IDA IDA: Inferred from direct assay	22864114	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEPACAM2 Protein Structure

V-set

I-set

Ig_2

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

HEPACAM family member 2

mitotic kinetics regulator

Related Diseases

Diseases

Alias

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Tumoral Calcinosis, Normophosphatemic, Familial

Normophosphatemic Familial Tumoral Calcinosis	NFTC
Tumoral Calcinosis, Familial, Normophosphatemic	Calcinosis, Tumoral, With Normophosphatemia
Familial Normophosphatemic Tumoral Calcinosis	Tumoral Calcinosis With Normophosphatemia

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06123	HEPACAM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HEPACAM2	VGNC	VGNC:29811
Canis familiaris	HEPACAM2	VGNC	VGNC:41658
Felis catus	HEPACAM2	VGNC	VGNC:62797
Mus musculus	HEPACAM2	MGD	MGI:2141520
Rattus norvegicus	HEPACAM2	RGD	RGD:1305697
Macaca mulatta	HEPACAM2	VGNC	VGNC:73247
Others	HEPACAM2	NCBI

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