Slc2a2 - solute carrier family 2 member 2 Gene

Rattus norvegicus

Also known as GTT2; Glut2

Gene ID: 25351 | Gene type: protein coding

About Slc2a2

Primary_assembly 2: 111,611,774-111,639,933 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 312 orthologues, 12 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 1233.6) and Kidney (RPKM 253.5).

Summary

Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and Insulin Receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a2 Products(1)

mRNA	Protein	Name
NM_012879.2	NP_037011.2	solute carrier family 2, facilitated glucose transporter member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	3048704	RGD
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	18668520	RGD
enables insulin receptor binding	IPI IPI: Inferred from physical interaction	15665515	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	3048704	RGD
involved in D-glucose transmembrane transport	IEP IEP: Inferred from expression pattern	12095416	RGD
involved in carbohydrate utilization	IMP IMP: Inferred from mutant phenotype	11834736	RGD
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	27568038	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	27568038	RGD
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	18668520	RGD
involved in fructose transmembrane transport	IEP IEP: Inferred from expression pattern	12095416	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12095416	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	12095416	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11325341	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	1468587	RGD
located in brush border	IDA IDA: Inferred from direct assay	12095416	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	17272350	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18668520	RGD
located in endosome	IDA IDA: Inferred from direct assay	15665515	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	3048704	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a2 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 2

GLUT-2	glucose transporter type 2, liver
solute carrier family 2 (facilitated glucose transporter), member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13164	SLC2A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13165	Slc2a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13166	Slc2a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a2	NCBI	NCBI:6514

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