CHRDL2 - chordin like 2 Gene

Homo sapiens

Also known as BNF1; CHL2

Gene ID: 25884 | Gene type: protein coding

About CHRDL2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,696,429-74,731,426 (from NCBI)

This gene has 9 transcripts (splice variants), 118 orthologues and 19 paralogues. Biased expression in gall bladder (RPKM 39.8), appendix (RPKM 39.3) and 4 other tissues.

Summary

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human Activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

CHRDL2 Products(7)

mRNA	Protein	Name
NM_001278473.3	NP_001265402.1	chordin-like protein 2 isoform 2 precursor
NM_001304390.2	NP_001291319.1	chordin-like protein 2 isoform 3
NM_001304391.2	NP_001291320.1	chordin-like protein 2 isoform 4
NM_001304415.2	NP_001291344.1	chordin-like protein 2 isoform 5
NM_001304416.2	NP_001291345.1	chordin-like protein 2 isoform 6
NM_001304417.2	NP_001291346.1	chordin-like protein 2 isoform 7
NM_015424.6	NP_056239.3	chordin-like protein 2 isoform 1 precursor

CHRDL2 Protein Structure

VWC

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

chordin-like protein 2

breast tumor novel factor 1

Related Diseases

Diseases

Alias

Immunodeficiency 36

IMD36	Activated Phosphoinositide 3-Kinase Delta Syndrome 2
Immunodeficiency, Type 36

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02658	CHRDL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHRDL2	RGD	RGD:1306179
Bos taurus	CHRDL2	VGNC	VGNC:27317
Canis familiaris	CHRDL2	VGNC	VGNC:39230
Felis catus	CHRDL2	VGNC	VGNC:60872
Macaca mulatta	CHRDL2	VGNC	VGNC:71081
Mus musculus	CHRDL2	MGD	MGI:1916371
Others	CHRDL2	NCBI

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