HINFP - histone H4 transcription factor Gene

Homo sapiens

Also known as MIZF; HiNF-P; ZNF743

Gene ID: 25988 | Gene type: protein coding

About HINFP

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,121,580-119,136,059 (from NCBI)

This gene has 14 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 6.2), lymph node (RPKM 4.3) and 25 other tissues.

Summary

This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

HINFP Products(17)

mRNA	Protein	Name
NM_001243259.2	NP_001230188.1	histone H4 transcription factor isoform 2
NM_001351957.2	NP_001338886.1	histone H4 transcription factor isoform 3
NM_001351958.2	NP_001338887.1	histone H4 transcription factor isoform 1
NM_001351959.2	NP_001338888.1	histone H4 transcription factor isoform 1
NM_001351960.2	NP_001338889.1	histone H4 transcription factor isoform 1
NM_001351961.2	NP_001338890.1	histone H4 transcription factor isoform 4
NM_001351962.2	NP_001338891.1	histone H4 transcription factor isoform 4
NM_001351963.2	NP_001338892.1	histone H4 transcription factor isoform 5
NM_001351964.2	NP_001338893.1	histone H4 transcription factor isoform 5
NM_001351965.2	NP_001338894.1	histone H4 transcription factor isoform 6
NM_001351966.2	NP_001338895.1	histone H4 transcription factor isoform 6
NM_001351969.2	NP_001338898.1	histone H4 transcription factor isoform 6
NM_001351971.2	NP_001338900.1	histone H4 transcription factor isoform 6
NM_001351972.2	NP_001338901.1	histone H4 transcription factor isoform 6
NM_001351974.2	NP_001338903.1	histone H4 transcription factor isoform 6
NM_015517.5	NP_056332.2	histone H4 transcription factor isoform 1
NM_198971.3	NP_945322.1	histone H4 transcription factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9540062	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18850719	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	9540062	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18850719	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11553631	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	9540062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11553631	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	14752047	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17974976	GOA
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	17974976	GOA
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	14585971	GOA
involved in cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15988025	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	15988025	GOA
involved in myoblast differentiation	IMP IMP: Inferred from mutant phenotype	15541338	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11553631	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15541338	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14585971	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	14585971	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18850719	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9540062	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	15988025	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	11553631	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	11553631	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14585971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HINFP Protein Structure

zf-H2C2_2

zf-C2H2_4

zf-C2H2

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

histone H4 transcription factor

MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein

Related Diseases

Diseases

Alias

Cerebrooculofacioskeletal Syndrome 2

COFS2	Cerebro-Oculo-Facio-Skeletal Syndrome 2
Cofs Syndrome

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06175	HINFP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HINFP	RGD	RGD:1311492
Canis familiaris	HINFP	VGNC	VGNC:50633
Mus musculus	HINFP	MGD	MGI:2429620
Macaca mulatta	HINFP	VGNC	VGNC:73408
Bos taurus	HINFP	VGNC	VGNC:50615
Felis catus	HINFP	VGNC	VGNC:62816

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