Ceacam1 - CEA cell adhesion molecule 1 Gene

Mus musculus

Also known as Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a

Gene ID: 26365 | Gene type: protein coding

About Ceacam1

Summary

Enables several functions, including signaling receptor binding activity; virion binding activity; and virus receptor activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including modulation by host of viral process; regulation of T cell activation; and regulation of intracellular signal transduction. Located in cell projection membrane; external side of plasma membrane; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ceacam1 Products(4)

mRNA	Protein	Name
NM_001039185.1	NP_001034274.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor
NM_001039186.1	NP_001034275.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor
NM_001039187.1	NP_001034276.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor
NM_011926.2	NP_036056.2	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	22496641	MGI
enables granulocyte colony-stimulating factor receptor binding	IPI IPI: Inferred from physical interaction	21029969	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15467833	MGI
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	22496641	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	21081647	MGI
involved in cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	23800882	MGI
involved in common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	21029969	MGI
involved in granulocyte colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	21029969	MGI
involved in insulin catabolic process	IMP IMP: Inferred from mutant phenotype	18544705	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17081782	MGI
acts upstream of or within negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	25490771	MGI
acts upstream of or within negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	17081782	MGI
involved in negative regulation of granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	21029969	MGI
involved in negative regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	15467833	MGI
involved in negative regulation of interleukin-1 production	IMP IMP: Inferred from mutant phenotype	22496641	MGI
involved in negative regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	18544705	MGI
involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: Inferred from mutant phenotype	23696226	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	25490771	MGI
involved in negative regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	19008452	MGI
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	22496641	MGI
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	21081647	MGI
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	22962327	MGI
involved in regulation of blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	16680193	MGI
involved in regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	16680193	MGI
involved in regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	16680193	MGI
involved in regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15467833	MGI
involved in regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	16680193	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19008452	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	22179047	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23123061	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	22179047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carcinoembryonic antigen-related cell adhesion molecule 1

BGP-1	CEA-related cell adhesion molecule 1
MHV-R	biliary glycoprotein 1
biliary glycoprotein D	carcinoembryonic antigen 1
carcinoembryonic antigen 7	hepatitis virus (MHV-4) susceptibility
hepatitis virus receptor	murine hepatitis virus receptor

Recombinant Ceacam1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75360	CEACAM1 Protein, Mouse (HEK293, Fc)	Q925P3/NP_001034274.1 (E35-G428)	≥95%
HY-P77630	CEACAM1 Protein, Mouse (HEK293, His)	P31809-1 (E35-G428)	≥95%
HY-P77632	CLEC5A/MDL-1 Protein, Human (HEK293, Fc)	Q9NY25 (Y26-K188)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163028	ML-T7		99.93%	Unkown
HY-155175	TIM-3-IN-2	Inhibitor	99.36%	Unkown
HY-159884	MG-T-19		/	Unkown
HY-RS02435	CEACAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ceacam1	NCBI	NCBI:634
Canis familiaris	Ceacam1	NCBI	NCBI:612435
Rattus norvegicus	Ceacam1	NCBI	NCBI:81613

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