Map2k1 - mitogen-activated protein kinase kinase 1 Gene

Mus musculus

Also known as Mek1; MEKK1; MAPKK1; Prkmk1

Gene ID: 26395 | Gene type: protein coding

About Map2k1

Chromosome 9: 64,093,052-64,160,913 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 22 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 5.3), cortex adult (RPKM 32.1) and 27 other tissues.

Summary

Enables MAP kinase kinase activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and neurogenesis. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 Products(2)

mRNA	Protein	Name
NM_008927.5	NP_032953.1	dual specificity mitogen-activated protein kinase kinase 1 isoform 1
NM_001410474.1	NP_001397403.1	dual specificity mitogen-activated protein kinase kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	1411546	MGI
enables MAP kinase kinase activity	IMP IMP: Inferred from mutant phenotype	11841548	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10523642	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23283332	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Bergmann glial cell differentiation	IGI IGI: Inferred from genetic interaction	24431450	MGI
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	24493648	MGI
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	25100655	MGI
involved in MAPK cascade	IGI IGI: Inferred from genetic interaction	21220101	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	24493648	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within cell motility	IMP IMP: Inferred from mutant phenotype	10209122	MGI
acts upstream of or within cerebellar cortex formation	IGI IGI: Inferred from genetic interaction	24431450	MGI
acts upstream of endodermal cell differentiation	IDA IDA: Inferred from direct assay	16908534	MGI
acts upstream of or within epithelial cell proliferation involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	25100655	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	18952847	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21699731	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	11841548	MGI
acts upstream of or within labyrinthine layer development	IMP IMP: Inferred from mutant phenotype	10209122	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	25100655	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15145949	MGI
acts upstream of or within placenta blood vessel development	IMP IMP: Inferred from mutant phenotype	10209122	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15896720	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within positive regulation of endodermal cell differentiation	IDA IDA: Inferred from direct assay	16908534	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	19047410	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15896720	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within trachea formation	IGI IGI: Inferred from genetic interaction	25100655	MGI
acts upstream of positive effect type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	18202127	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k1 Protein Structure

PKc_MEK1

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 1

ERK activator kinase 1	MAP kinase kinase 1
MAPK/ERK kinase 1	protein kinase, mitogen activated, kinase 1, p45

Recombinant Map2k1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73825	MEK1 Protein, Mouse (sf9, His-GST)	P31938 (M1-I393)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k1	NCBI	NCBI:5604

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