NR6A1 - nuclear receptor subfamily 6 group A member 1 Gene

Homo sapiens

Also known as RTR; GCNF; NR61; hRTR; CT150; GCNF1; hGCNF

Gene ID: 2649 | Gene type: protein coding

About NR6A1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,517,275-124,771,311 (from NCBI)

This gene has 5 transcripts (splice variants) and 227 orthologues. Biased expression in testis (RPKM 11.0), thyroid (RPKM 1.5) and 7 other tissues.

Summary

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

NR6A1 Products(4)

mRNA	Protein	Name
NM_001278546.2	NP_001265475.1	nuclear receptor subfamily 6 group A member 1 isoform 4
NM_001410996.1	NP_001397925.1	nuclear receptor subfamily 6 group A member 1 isoform 5
NM_001489.5	NP_001480.3	nuclear receptor subfamily 6 group A member 1 isoform 2
NM_033334.4	NP_201591.2	nuclear receptor subfamily 6 group A member 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR6A1 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 6 group A member 1

retinoic acid receptor-related testis-associated receptor

Related Diseases

Diseases

Alias

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09555	NR6A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR6A1	VGNC	VGNC:32250
Canis familiaris	NR6A1	VGNC	VGNC:49931
Macaca mulatta	NR6A1	VGNC	VGNC:75522
Rattus norvegicus	NR6A1	RGD	RGD:1564740
Felis catus	NR6A1	VGNC	VGNC:68558
Mus musculus	NR6A1	MGD	MGI:1352459
Others	NR6A1	NCBI

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