2. Gene
  3. AMELY - amelogenin Y-linked Gene

AMELY - amelogenin Y-linked Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMGL; AMGY

Gene ID: 266 | Gene type: protein coding

About AMELY

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:6,865,918-6,911,752 (from NCBI)

This gene has 2 transcripts (splice variants), 7 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008]

AMELY Products(2)

mRNA Protein Name
NM_001143.2 NP_001134.1 amelogenin, Y isoform isoform 1 precursor
NM_001364814.1 NP_001351743.1 amelogenin, Y isoform isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables structural constituent of tooth enamel IDA
IDA: Inferred from direct assay
1734713 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMELY Protein Structure

Amelogenin

Amelogenin: Amelogenin (17 - 206)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

amelogenin, Y isoform

amelogenin (Y chromosome)

Related Diseases

Diseases Alias
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99308 Ocaratuzumab Inhibitor 95.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00648 AMELY Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00649 AMER1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00650 AMER2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00651 AMER3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AMELY MGD MGI:88005