SLCO3A1 - solute carrier organic anion transporter family member 3A1 Gene

Homo sapiens

Also known as OATPD; OATP-D; OATP3A1; OATPRP3; OATP-RP3; SLC21A11

Gene ID: 28232 | Gene type: protein coding

About SLCO3A1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:91,853,708-92,172,435 (from NCBI)

This gene has 13 transcripts (splice variants), 264 orthologues and 10 paralogues. Broad expression in testis (RPKM 11.4), lung (RPKM 6.4) and 23 other tissues.

Summary

Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and prostaglandin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLCO3A1 Products(2)

mRNA	Protein	Name
NM_001145044.1	NP_001138516.1	solute carrier organic anion transporter family member 3A1 isoform 2
NM_013272.4	NP_037404.2	solute carrier organic anion transporter family member 3A1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	24945726	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24945726	GOA
involved in prostaglandin transport	IDA IDA: Inferred from direct assay	14631946	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21278488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO3A1 Protein Structure

OATP

Kazal_2

0
200
400
600
710 a.a.

Protein Preferred Names

Protein Names

solute carrier organic anion transporter family member 3A1

PGE1 transporter

Related Diseases

Diseases

Alias

Intestinal Perforation

Perforation Of Intestine

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13357	SLCO3A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLCO3A1	RGD	RGD:620227
Felis catus	SLCO3A1	VGNC	VGNC:65446
Canis familiaris	SLCO3A1	VGNC	VGNC:46497
Macaca mulatta	SLCO3A1	VGNC	VGNC:77598
Bos taurus	SLCO3A1	VGNC	VGNC:34953
Mus musculus	SLCO3A1	MGD	MGI:1351867

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