FAM98B - family with sequence similarity 98 member B Gene

Homo sapiens

Gene ID: 283742 | Gene type: protein coding

About FAM98B

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:38,454,127-38,487,710 (from NCBI)

This gene has 4 transcripts (splice variants), 100 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.0), endometrium (RPKM 8.6) and 25 other tissues.

Summary

Enables identical protein binding activity and protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Located in cytoplasm and nucleoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

FAM98B Products(1)

mRNA	Protein	Name
NM_173611.4	NP_775882.2	protein FAM98B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	28040436	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24608264	GOA
enables protein methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28040436	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28040436	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28040436	GOA
involved in protein methylation	IMP IMP: Inferred from mutant phenotype	28040436	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18445686	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24608264	GOA
part of tRNA-splicing ligase complex	IDA IDA: Inferred from direct assay	21311021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM98B Protein Structure

DUF2465

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

protein FAM98B

Related Diseases

Diseases

Alias

Spastic Paraplegia 11, Autosomal Recessive

SPG11	Hereditary Spastic Paraplegia 11
Hsp-Tcc	Autosomal Recessive Spastic Paraplegia Type 11
Nakamura-Osame Syndrome	Spastic Paraplegia-Intellectual Disability-Thin Corpus Callosum Syndrome
Spastic Paraplegia, Autosomal Recessive, With Mental Impairment And Thin Corpus Callosum	Spastic Paraplegia, Autosomal Recessive, Complicated, With Thin Corpus Callosum
Autosomal Recessive Spastic Paraplegia 11	Autosomal Recessive Spastic Paraplegia Complicated With Thin Corpus Callosum
Autosomal Recessive Spastic Paraplegia With Mental Impairment And Thin Corpus Callosum	Arhsp-Tcc
Autosomal Recessive Spastic Paraplegia With Thinning Of Corpus Callosum	Spastic Paraplegia Autosomal Recessive Complicated With Thin Corpus Callosum
Spastic Paraplegia Autosomal Recessive With Mental Impairment And Thin Corpus Callosum	Paraplegia, Spastic, Autosomal Recessive, Type 11
Nakamura Osame Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04729	FAM98B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM98B	RGD	RGD:1564603
Macaca mulatta	FAM98B	VGNC	VGNC:72583
Mus musculus	FAM98B	MGD	MGI:1915465
Felis catus	FAM98B	VGNC	VGNC:104389
Canis familiaris	FAM98B	VGNC	VGNC:40713
Bos taurus	FAM98B	VGNC	VGNC:28849

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