ENDOV - endonuclease V Gene

Homo sapiens

Gene ID: 284131 | Gene type: protein coding

About ENDOV

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,415,167-80,438,086 (from NCBI)

This gene has 30 transcripts (splice variants) and 175 orthologues. Ubiquitous expression in testis (RPKM 3.1), prostate (RPKM 2.3) and 25 other tissues.

Summary

Enables DNA binding activity; endoribonuclease activity, producing 5'-phosphomonoesters; and single-stranded RNA binding activity. Predicted to be involved in DNA repair. Located in cytoplasmic stress granule and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ENDOV Products(5)

mRNA	Protein	Name
NM_001164637.3	NP_001158109.1	endonuclease V isoform 2
NM_001164638.3	NP_001158110.1	endonuclease V isoform 3
NM_001352760.3	NP_001339689.1	endonuclease V isoform 4
NM_001352761.3	NP_001339690.1	endonuclease V isoform 5
NM_173627.5	NP_775898.2	endonuclease V isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	23139746	GOA
enables RNA endonuclease activity, producing 5'-phosphomonoesters	IDA IDA: Inferred from direct assay	3170309	GOA
NOT enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters	IDA IDA: Inferred from direct assay	23139746	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27573237	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	23912683	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23139746	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27573237	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	23139746	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENDOV Protein Structure

Endonuclease_5

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

endonuclease V

hEndoV

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Cockayne Syndrome B

Cockayne Syndrome Type 2	Cockayne Syndrome, Type B
Cockayne Syndrome Type Ii	CSB
Cockayne Syndrome 2	Cockayne Syndrome Type B
Ckn2	Cockayne Syndrome, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04373	ENDOV Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENDOV	RGD	RGD:1562414
Mus musculus	ENDOV	MGD	MGI:2444688
Canis familiaris	ENDOV	VGNC	VGNC:40361
Felis catus	ENDOV	VGNC	VGNC:61860
Bos taurus	ENDOV	VGNC	VGNC:28492

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